The relationship between enlarged perivascular spaces in the hippocampus and cognitive function in patients with type 2 diabetes mellitus
10.3969/j.issn.1002-1671.2024.09.001
- VernacularTitle:2型糖尿病海马血管周围间隙扩大与认知功能的相关性研究
- Author:
Peichun PAN
1
;
Jie GAO
;
Jing LI
;
Jialu SUN
;
Dongsheng ZHANG
;
Min TANG
;
Xiaoling ZHANG
Author Information
1. 陕西中医药大学医学技术学院,陕西 咸阳 712046
- Keywords:
type 2 diabetes mellitus;
magnetic resonance ima-ging;
hippocampus;
enlarged perivascular spaces
- From:
Journal of Practical Radiology
2024;40(9):1399-1402
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between enlarged perivascular spaces in the hippocampus(H-EPVS)and cognitive function in patients with type 2 diabetes mellitus(T2DM),and to explore whether the H-EPVS can be used as an imaging marker of cognitive impairment in T2DM.Methods A total of 93 T2DM patients were selected(including 56 patients with cognitive impair-ment and 37 patients with normal cognition).All patients received head MRI scanning and neuropsychological tests.The differences of the H-EPVS counts and various parameters between the two groups were compared.Multiple linear regression was used to evalu-ate the association between H-EPVS and cognitive function.Results Compared with the T2DM patients with normal cognition,the cognitive impairment had significantly higher total H-EPVS counts(P=0.015),and worse performance of global cognitive function,processing speed,immediate memory and delayed recall(P＜0.05).After adjusting for confounding factors by multiple linear regres-sion,total H-EPVS were associated with global cognitive function and immediate memory.Conclusion The H-EPVS are correlated with global cognitive function and memory function in patients with T2DM.The H-EPVS may be used as an imaging marker of cog-nitive impairment in T2DM patients.
