Meta-analysis of anti-GP210 antibody and anti-SP100 antibody detection for diagnosis of primary biliary cirrhosis
10.3760/cma.j.issn.1007-3418.2016.01.012
- VernacularTitle:抗核孔膜蛋白和抗核体蛋白抗体对原发性胆汁性肝硬化诊断价值的meta分析
- Author:
Hongmei DENG
1
;
Shiling HU
;
Weixian CHEN
;
Ying HUANG
Author Information
1. 400010,重庆医科大学附属第二医院感染科 感染性疾病分子生物学教育部重点实验室 病毒性肝炎研究所
- Keywords:
Primary biliary cirrhosis;
Meta-analysis;
Anti-GP210 antibody;
Anti-SP100 antibody
- From:
Chinese Journal of Hepatology
2016;24(1):62-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To conduct a systematic review of studies assessing the association of anti-GP210 antibody and anti-SP100 antibody with diagnosis of primary biliary cirrhosis (PBC) using meta-analysis.Methods Five research literature databases,including the Cochrane Library,MEDLINE,VIP,CNKI and WanFang,were searched for studies of anti-GP210 antibody and anti-SP100 antibody in diagnosis of PBC.Meta-disc statistical software was used for analysis.Results The meta-analysis included a total of 25 studies on anti-GP210 antibody and 21 studies on anti-SP100 antibody.The diagnostic odds ratio,sensitivity,and specificity of anti-GP210 antibody for diagnosis of PBC were 24.854 (11.957-51.660),0.272 (0.257-0.288),and 0.985 (0.982-0.988),respectively,and for anti-SP100 antibody they were 9.133 (4.739-17.600),0.231 (0.213-0.249),and 0.977 (0.973-0.981),respectively.Conclusions Both anti-GP210 antibody and anti-SP100 antibody show high specificity but low sensitivity in diagnosis of PBC.
