Quantitative MRI analysis of hepatic and pancreatic fat content in patients with type 2 diabetes mellitus and the relationship with pancreatic β-cell function and bone mineral density
10.3969/j.issn.1002-1671.2024.08.019
- VernacularTitle:定量MRI分析2型糖尿病患者肝胰脂肪含量与胰岛β细胞功能、骨密度的关系
- Author:
Xiaobin ZHENG
1
;
Jie DENG
;
Yikun ZHU
Author Information
1. 长治医学院附属和济医院影像科,山西 长治 046011
- Keywords:
type 2 diabetes mellitus;
hepatic and pancreatic fat content;
quantitative MRI analysis;
pancreatic β-cell function;
bone mineral density
- From:
Journal of Practical Radiology
2024;40(8):1304-1307,1353
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of hepatic and pancreatic fat content in patients with type 2 diabetes mellitus(T2DM)using quantitative MRI,and to discuss the relationship with pancreatic β-cell function and bone mineral density(BMD).Methods A total of 118 patients with T2DM(T2DM group)were selected as the research subjects.At the same time,100 healthy control(HC)(HC group)who received physical examination were selected.All patients were examined with MRI.Hepatic fat fraction(HFF)and pancreatic fat fraction(PFF)were detected using the iterative decomposition of water and fat with echo asymmetry and least square estimation quantitation(IDEAL-1Q)technology.The homeostasis model assessment of β-cell function(HOMA-β)and homeostasis model assessment of insulin resistance(HOMA-IR)were performed.BMD of L2-L4,femoral neck and total hip were measured by dual-energy X-ray absorptiometry.The correlations among HFF,PFF and HOMA-β,HOMA-IR and BMD of L2-L4,femoral neck and total hip were analyzed by Pearson method.Results HFF and PFF in the T2DM group[(14.12±2.19)％and(8.23±1.60)％]were higher than those in the HC group[(5.30±0.83)％and(4.36±0.85)％],with statistically significant differences(P＜0.05).HOMA-βand BMD of L2-L4,femoral neck and total hip in the T2DM group[14.50±3.63,(0.92±0.13)mg/cm3,(0.77±0.10)mg/cm3 and(0.83±0.12)mg/cm3]were lower than those in the HC group[25.22±5.43,(1.05±0.23)mg/cm3,(0.85±0.18)mg/cm3 and(0.91±0.20)mg/cm3].HOMA-IR in the T2DM group(3.56±1.22)was higher than that in the HC group(1.90±0.45).The differences were statistically significant(P＜0.05).Pearson correlation analysis found that HFF and PFF were negatively correlated with HOMA-β and BMD of L2-L4,femoral neck and total hip,and were positively correlated with HOMA-IR(P＜0.05).Conclusion MRI can be used to quantitatively evaluate hepatic and pancreatic fat content in patients with T2DM.In addition,hepatic and pancreatic fat content are closely related to pancreatic HOMA-β,HOMA-IR and BMD.
