Prediction of benign and malignant amorphous calcifications in the breast based on clinical and mammographic features
10.3969/j.issn.1002-1671.2024.08.013
- VernacularTitle:基于临床及乳腺X线影像特征对乳腺无定形钙化良恶性的预测研究
- Author:
Xinxin LI
1
,
2
;
Huiyu DUAN
;
Xiaomin TANG
;
Dawei ZHOU
;
Xiuting CHEN
;
Chengcheng MA
;
Jing YAN
;
Zhizhen GAO
Author Information
1. 蚌埠医科大学第一附属医院放射科,安徽 蚌埠 233004
2. 蚌埠医科大学研究生院,安徽 蚌埠 233030
- Keywords:
mammography;
microcalcification;
nomogram;
breast cancer
- From:
Journal of Practical Radiology
2024;40(8):1276-1280
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors affecting the malignancy of amorphous calcifications in the breast and to establish a predictive nomogram.Methods Patients with amorphous calcifications detected by mammography were retrospectively collected,clinical data were obtained from electronic medical record(EMR),and the mammographic features of the patients were assessed by diagnostic physicians.The risk factors affecting the malignancy of amorphous calcifications were analyzed to develop a predictive model and to assess the performance of the model.Results A total of 153 amorphous calcifications in 144 patients were included in the study,and the overall malignancy rate of calcifications was 20.92％.Patient's age ≥45 years,linear distribution of calcifications,unilateral single or unilateral multiple calcifications,and a larger maximum ratio of calcification extent all predicted a higher probability of malignancy,establishing a nomogram based on these 4 risk factors,with a 3.65％predicted probability of malig-nancy as the cut-off,33.99％(52/153)of patients were allowed to be spared biopsy.Conclusion Patient's age and the distribution,number,and maximum ratio of calcifications may be the risk predictors of malignancy for amorphous calcifications,with nomogram con-struction for distinguishing benignity from malignancy of amorphous calcifications via combining with mammographic features and clinical data.
