Feasibility study of multi-parameters prediction of vulnerability of coronary plaque based on perivascular adipose tissue
10.3969/j.issn.1002-1671.2024.08.011
- VernacularTitle:冠状动脉血管周围脂肪组织多参数预测冠状动脉斑块易损性的可行性研究
- Author:
Yichao LIU
1
;
Chao WANG
;
Xiaohui QIU
Author Information
1. 亳州市人民医院影像中心,安徽 亳州 236800
- Keywords:
coronary computed tomography;
vulnerable plaque;
perivascular adipose tissue
- From:
Journal of Practical Radiology
2024;40(8):1267-1271
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the vulnerability of coronary plaques and parameters of perivascular adipose tissue(PVAT),and to assess the feasibility of predicting vulnerable plaques based on PVAT-related parameters.Methods A retrospective analysis was conducted on 199 patients,who were clinically suspected of coronary heart disease and underwent coronary computed tomography angiography(CCTA)examination,with a total of 230 lesion vessels and 230 plaques were analyzed.The vulnerability of plaques and the degree of vascular stenosis were evaluated.The pericoronary fat attenuation index(FAI),pericoronal fat total volume of voxels(FV)and pericoronary non-fat attenuation index(non-FAI)were measured,and the volumetric perivascular characterization index(VPCI)was calculated.The relationship between plaque vulnerability and PVAT parameters was statistically analyzed,and vulnerable plaques were predicted based on PVAT parameters.Results Non-vulnerable plaques were more likely to cause mild and moderate stenosis than vulnerable plaques,vulnerable plaques were more likely to cause severe stenosis than non-vulnerable plaques(P＜0.001,P=0.001).The FAI,non-FAI,and VPCI values of the vulnerable plaque group were higher than those of the non-vulnerable plaque group,while the FV value was lower than that of the non-vulnerable plaque group,and the differences were statistically significant(P＜0.01).The FAI value of the vulnerable plaque group was higher than the non-FAI value,with a statistically significant difference(P＜0.01),while there was no statistically significant difference between the FAI and non-FAI of the non-vulnerable plaque group(P＞0.05).The diagnostic efficiency of FAI,non-FAI,VPCI,FV values and the combined application of the four parameters for predicting vulnerable plaques were 0.753,0.624,0.770,0.755 and 0.837,respectively.Conclusion The occurrence rate of severe vascular stenosis,FAI,non-FAI,and VPCI values of vulnerable plaques are higher than those of non-vulnerable plaques,while the FV value is lower than that of non-vulnerable plaques.PVAT-related parameters have predictive value for vulnerable plaques.
