Histogram of diffusion kurtosis imaging to predict isocitrate dehydrogenase mutations and grade in adult gliomas
10.3969/j.issn.1002-1671.2024.08.003
- VernacularTitle:扩散峰度成像直方图预测成人胶质瘤异拧檬酸脱氢酶突变及级别
- Author:
Yahong QIN
1
;
Lei YAN
;
Ying XU
;
Yi WU
Author Information
1. 山西省中西医结合医院放射科,山西 太原 030013
- Keywords:
glioma;
isocitrate dehydrogenase;
diffusion kurtosis imaging;
histogram analysis
- From:
Journal of Practical Radiology
2024;40(8):1228-1232
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic efficacy of diffusion kurtosis imaging(DKI)histograms in predicting isocitrate dehydrogenase(IDH)mutations and grade in gliomas.Methods Sixty-four patients with pathologically confirmed gliomas with IDH gene phenotype results were included,all of whom underwent DKI,and mean kurtosis(MK)and mean diffusivity(MD)maps were generated.The whole tumor was outlined on the MK and MD maps in all slices,and histograms of the full tumor volume MK and MD were calculated.The histogram parameters between IDH mutant and wild type gliomas,and the MK and MD histogram parameters between high grade glioma(HGG,grade 3-4)and low grade glioma(LGG,grade 2)were compared.Receiver operating characteristic(ROC)curve was used to assess the predictive efficacy in determining IDH gene phenotype and grade of gliomas in statistically different parameters.Results Of the 64 gliomas,39 were IDH mutant and 25 were IDH wild type.The MKmax and MK90th in IDH mutant gliomas were lower than that in IDH wild type,while the MDmin,MD10th and MD30th were greater than that in IDH wild type.The area under the curve(AUC)of MKmax was 0.883 in differentiation of the IDH mutant and the IDH wild type,and when the MKmax was greater than 0.745,its sensitivity and specificity in predicting IDH mutations were 81.8％and 82.4％,respectively.There were 28 cases of LGG and 36 cases of HGG;the MKmax,MK70th,and MK90th of HGG were greater than that of LGG,while the MDmin and MD10th were lower than that of LGG,in which the MD10th had an AUC of 0.886 in differentiation of HGG and LGG,when MD10th was greater than 1.075 × 10-3 mm2/s,its sensitivity and specificity in predicting HGG were 85.7％and 86.1％,respectively.Conclusion The MKmax in the DKI histogram has the highest predictive efficacy in the IDH phenotype,while the MD10th has the best diagnostic value for glioma grade.
