Clinical efficacy of urokinase combined with tirofiban treatment for acute cerebral infarction with digital subtraction angiography negative
10.3969/j.issn.1002-1671.2024.07.026
- VernacularTitle:尿激酶联合替罗非班治疗数字减影血管造影阴性的急性脑梗死的临床疗效
- Author:
Rui QI
1
;
Jing WANG
;
Zhifeng BAI
Author Information
1. 北京丰台右安门医院神经介入科,北京 100069
- Keywords:
acute cerebral infarction;
urokinase;
tirofiban;
digital subtraction angiography
- From:
Journal of Practical Radiology
2024;40(7):1151-1155
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of urokinase arterial thrombolysis combined with tirofiban sequential therapy in acute cerebral infarction with digital subtraction angiography(DS A)negative.Methods The clinical data of 82 acute cerebral infarction patients with DSA negative were collected.All patients were divided into the control group(n=41)and the observation group(n=41).The control group received routine treatment such as arterial thrombolysis and dual antiplatelet.The observation group was treated with arterial thrombolysis and intravenous tirofiban treatment for 36 h,and subsequent treatment was the same as the control group.The National Institutes of Health Stroke Scale(NIHSS)scores were analyzed at different time points including before,during,and after interven-tion.The modified Rankin scale(mRS)scores and changes in coagulation function were compared before and 90 d after intervention,and the incidence of complications of all patients were recorded.The differences of all indicators were analyzed.Results The NIHSS scores during and 30 d after intervention in the control group and at various time points during and after intervention in the observa-tion group were lower than those before intervention(P＜0.05).The NIHSS score of the observation group at various time point after intervention was significantly lower than those of the control group(P＜0.05).The clinical effective rate of the observation group 30 d after intervenion was significantly higher than those of the control group(92.68％vs 78.05％).The mRS scores of the two groups 90 d after intervention were significantly lower than those before intervention,and the observation group was significantly lower than the control group(P＜0.05).There were significant differences in prothrombin time(PT),thrombin time(TT),and fibrinogen(FIB)between the two groups 3 d after intervention compared to before intervention(P＜0.05).There was no difference in FIB and PT 7 d after intervention between the two groups(P＞0.05),while TT of the observation group was significantly higher than that of the control group(P=0.038).There was no significant difference in the incidence of complications between the two groups(P=0.073).Conclusion Urokinase arterial thrombolysis combined with tirofiban can effectively improve the neurological function and prognosis of acute cerebral infarction patients with DSA negative,shorten the recovery time,with good clinical safety.
