Correlation between high-resolution CT features and therapeutic effect in patient with non-tuberculous mycobacteria pulmonary disease
10.3969/j.issn.1002-1671.2024.07.008
- VernacularTitle:非结核分枝杆菌肺病高分辨率CT特征与疗效的相关性
- Author:
Zengwei LIU
1
,
2
;
Zhibo WEN
;
Huiru LI
;
Zhi'en XIE
;
Hua CHEN
Author Information
1. 南方医科大学珠江医院影像诊断科,广东 广州 510280
2. 广州市胸科医院放射科,广东 广州 510095
- Keywords:
non-tuberculous mycobacteria;
high-resolution computed tomography;
therapeutic effect
- From:
Journal of Practical Radiology
2024;40(7):1070-1074
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between high-resolution computed tomograohy(HRCT)features and thera-peutic effect in patient with non-tuberculous mycobacteria pulmonary disease(NTM-PD).Methods A total of 225 NTM-PD patients were divided into curative group and non-curative group according to the efficacy criteria,and the clinical and HRCT features between the two groups were compared.Correlation analysis and logistic regression analysis were used to screen the risk factors for potential poor efficacy,and their predictive value was evaluated by the receiver operating characteristic(ROC)curve.Results The proportion of cavities,the number of nodules and bronchiectasis involving lung lobes in the non-curative group were significantly higher than those in the curative group,while the body mass index(BMI)was significantly lower than that in the curative group.The distribution of non-tuberculous mycobacteria(NTM)strains,cavities,the number of nodules involving lung lobes,and the number of bronchiecta-sis involving lung lobes were positively correlated with poor efficacy,while BMI was negatively correlated with poor efficacy(P＜0.05).The distribution of NTM strains,the number of nodules and bronchiectasis involving lung lobes were independent risk factors for poor efficacy(P＜0.05).Cavities,the number of nodules involving lung lobes,and the number of bronchiectasis involving lung lobes alone or in combination had high efficacy in predicting poor efficacy,with the highest prediction value of the three combined model[area under the curve(AUC)=0.819;95％confidence interval(CI)0.762-0.876].Conclusion The combined model based on cavities,the number of nodules involving lung lobes,and the number of bronchiectasis involving lung lobes has the highest effi-ciency in predicting poor efficacy in NTM-PD patients.
