Assessment of different bone marrow infiltration patterns with MR whole-body diffusion weighted imaging in multiple myeloma
10.3969/j.issn.1002-1671.2024.06.021
- VernacularTitle:MR全身扩散加权成像评估多发性骨髓瘤不同骨髓浸润模式
- Author:
Yawen WU
1
;
Dongmei WANG
;
Hongwei CAO
;
Fengzhen CUI
;
Chengyuan XU
;
Jie LIU
;
Chengyu JIN
;
Boyi LI
;
Yuqing LI
Author Information
1. 杭州师范大学附属医院放射科,浙江 杭州 310015
- Keywords:
multiple myeloma;
magnetic resonance imaging;
whole-body diffusion weighted imaging;
bone marrow infiltration
- From:
Journal of Practical Radiology
2024;40(6):952-956
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the apparent diffusion coefficient(ADC)values of different bone marrow infiltration patterns in multiple myeloma(MM)patients with MR whole-body diffusion weighted imaging(WB-DWI)and to determine the ADC thresholds for different bone marrow infiltration patterns.Methods Nineteen MM patients diagnosed for the first time were selected.The lesions types of each site(cervical spine,ribs,sternum,humerus,scapula,sacral spine,ilium,femur,thoracic spine,and lumbar spine)after the WB-DWI images were visually evaluated,which were divided into focal group(including focal lesion in combined focal and diffuse infiltration)[region of interest(ROI)=141],pure diffuse infiltration group(ROI=150),diffuse lesion in combined focal and diffuse infiltration group(ROI=127),"salt-and-pepper"group(ROI=54),and normal appearance group(ROI=68).ADC values were measured and compared between each group and the receiver operating characteristic(ROC)curve was drawn to distinguish different patterns of bone marrow infiltration.Results There was no statistically significant difference in ADC values between the diffuse lesion in combined focal and diffuse infiltration group and the"salt-and-pepper"group(P＞0.99),and there was statistically significant difference in ADC values between the other groups(P＜0.05).The ROC curve showed that the area under the curve(AUC)for identifying focal group and the"salt-and-pepper"group was 0.889[95％confidence interval(CI)0.844-0.934],the AUC for identifying pure diffuse infiltration group and the normal appearance group was 0.968(95％CI 0.949-0.987).ADC values were able to accurately and visually differentiate between the different patterns of bone marrow infiltration.Conclusion The ADC values can be used as a quantitative tool to objectively distinguish different bone marrow infiltration patterns in MM patients.
