Assessment of high-resolution MR vessel wall imaging for plaques characteristics changes after lipid-lowering therapy in acute stroke patients
10.3969/j.issn.1002-1671.2024.06.005
- VernacularTitle:高分辨率MR血管壁成像评估急性脑卒中患者降脂治疗后斑块特征变化
- Author:
Yingshuai ZHANG
1
;
Zhigang PENG
;
Xinju GAO
;
Hongran LIU
;
Cuicui LIU
;
Xiaona LI
Author Information
1. 河北医科大学第三医院CT/MRI中心,河北 石家庄 050051
- Keywords:
high-resolution magnetic resonance vessel wall imaging;
acute stroke;
plaque characteristics;
lipid-lowering therapy
- From:
Journal of Practical Radiology
2024;40(6):880-883,887
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of standardized lipid-lowering therapy in acute stroke patients via high-resolution magnetic resonance vessel wall imaging(HRMR-VWI)to follow-up the characteristics changes of intracranial atherosclerotic plaques.Methods Twenty-two acute stroke patients(65 plaques)were enrolled,and their clinical and imaging data were collected on admission and after standardized lipid-lowering therapy(355-370 days).Diffusion weighted imaging(DWI),three-dimensional time of flight magnetic resonance angiography(3D-TOF-MRA),and HRMR-VWI were performed in all patients.According to the changes in non-high density lipoprotein(non-HDL),all patients were divided into the effective lipid-lowering group and the ineffective lipid-lowering group.The demographic information,plaques characteristics and the effect of standardized lipid-lowering therapy of all patients were compared.Results One(2.33％)plaque in the effective group showed reverse remodeling and four(18.18％)new plaques in the anterior circulation in the ineffective group.Patients in the effective group were significantly better than those in the ineffective group in terms of plaque thickness,load,remodeling index(RI),and the rate of increase in plaque thickness,load,stenosis,and RI,with statistically significant difference(P＜0.05).There was no statistical significance in the rate of stenosis between the two groups.Conclusion Standardized lipid-lowering therapy has differences in the prognosis of acute stroke patients,and HRMR-VWI may be conducive to individualized assessment of the lipid-lowering effect.
