Correlation analysis of MRI characteristics with MGMT and Ki-67 in IDH wild-type glioblastoma located in the subventricular zone
10.3969/j.issn.1002-1671.2024.06.003
- VernacularTitle:室管膜下区IDH野生型胶质母细胞瘤的MRI表现与MGMT及Ki-67相关性分析
- Author:
Sifan QIU
1
,
2
;
Zhihong KE
;
Lidan LIN
;
Yanuo HU
;
You ZHANG
;
Shangwen XU
Author Information
1. 福建医科大学福总临床医学院,福建 福州 350025
2. 中国人民解放军联勤保障部队第九○○医院放射诊断科,福建 福州 350025
- Keywords:
IDH wild-type glioblastoma;
subventricular zone;
Ki-67;
MGMT promoter methylation
- From:
Journal of Practical Radiology
2024;40(6):870-874
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the MRI characteristics of subventricular zone(SVZ)-associated isocitrate dehydrogenase(IDH)wild-type glioblastoma(GBM)and their correlations with Ki-67 expression and O6-methylguanine-DNA methyltransferase(MGMT)promoter methylation status.Methods A retrospective analysis was conducted on data of 78 patients with IDH wild-type GBM who underwent surgery and received pathological confirmation.Preoperative MRI contrast-enhanced T1 WI sequences were used to assess SVZ involvement,and postoperative molecular testing of tumor markers,including Ki-67 expression and MGMT methylation status,was utilized to categorize the patients accordingly.Results The SVZ involved(+)group(P＜0.001)and the MGMT(+)group(P=0.036)exhibited significantly larger tumor volumes.There were no significant differences between the groups in terms of gender,age,left/right hemispheric lateralization,or specific brain lobe distribution.There was no significant association between Ki-67 expression levels,MGMT methylation status,and SVZ involvement,respectively.Conclusion The SVZ(+)group and the MGMT(+)group demonstrates a wider range of tumor invasion.
