An in vitro study of the effect of iron on measurement of bone mineral density by quantitative CT
10.3969/j.issn.1002-1671.2024.05.033
- VernacularTitle:铁对定量CT骨密度测量影响的体外研究
- Author:
Fanping ZENG
1
,
2
;
Zifeng HUANG
;
Lianjie HU
;
Chunyan LI
Author Information
1. 广西医科大学,广西 南宁 530021
2. 广西医科大学第一附属医院放射科,广西 南宁 530021
- Keywords:
iron-containing water model;
quantitative computed tomography;
bone mineral density;
correction equation
- From:
Journal of Practical Radiology
2024;40(5):821-824,844
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of iron on measurement of bone mineral density(BMD)by quantitative computed tomography(QCT)and to establish a correction equation to exclude the effect of iron by using R2*.Methods A total of 15 water models containing different concentrations of iron were prepared by analyzing pure anhydrous calcium chloride and 100 mg/mL iron dextran injection.Each water model was scanned by CT and MRI under the same conditions,and the CT,QCT BMD and R2*val-ues were measured.The correlation analysis was performed between iron concentration and CT value,and QCT BMD value.Simple linear regression analysis was performed between iron concentration and QCT BMD value,between QCT BMDiron and R2*.Results There was a significant positive correlation between iron concentration and CT value,and QCT BMD value(rCT value=0.994,P＜0.001,rQCT BMD=0.993,P＜0.001).The simple linear regression equation between iron concentration and QCT BMD value was established:y=2.34x+159(x:iron concentration,y:QCT BMD).The correction equation was:QCT BMDcorrection=QCT BMDmeasurement-0.093 R2*+0.434.Conclusion Under ideal conditions,iron has an effect on measurement of BMD by QCT,and iron reduces the accuracy of measure-ment of BMD by QCT.The effect of iron on measurement of BMD by QCT needs to be corrected by correction equation.
