The value of volume percentage of solid component differentiate and diagnose early stage lung adenocarcinoma subtypes
10.3969/j.issn.1002-1671.2024.05.006
- VernacularTitle:实变肿瘤体积比鉴别诊断早期肺腺癌亚型的价值
- Author:
Xiaoyan QU
1
;
Gangfeng LI
;
Yang YANG
;
Pan AN
;
Xingyi HOU
;
Ya GAO
;
Yuanbo ZHU
;
Lu YANG
;
Zhiying MA
;
Guangbin CUI
Author Information
1. 空军军医大学唐都医院放射科,陕西 西安 710038
- Keywords:
lung adenocarcinoma;
subsolid pulmonary nodules;
CT density histogram analysis;
volume percentage of solid component
- From:
Journal of Practical Radiology
2024;40(5):709-712,720
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of the volume percentage of solid component in differential diagnosis of stage Ⅰ lung adenocarcinoma subtypes,and to predict the optimal critical CT value of solid component.Methods A total of 962 nodules with sur-gical pathological findings confirmed as adenocarcinoma in situ(AIS)or pulmonary adenocarcinoma and manifested as subsolid nod-ules on thin-section CT were analyzed retrospectively,and divided the lesions into:(1)AIS(n=350)or pulmonary adenocarcinoma(n=612)groups;and(2)minimally invasive adenocarcinoma(MIA)(n=213)or invasive adenocarcinoma(IAC)(n=399)groups based on pathological findings.The volume percentage of solid components within pulmonary nodules was measured via CT density histogram analysis at different thresholds,the diagnostic efficacy of different thresholds was analyzed and the optimal critical CT val-ues of solid component was found.Results In the AIS versus pulmonary adenocarcinoma groups,age,mass,and volume percentage of solid component were statistically significant(P＜0.001);the CT threshold of-350 HU had the highest diagnostic efficacy[area under the curve(AUC)0.859,accuracy 81.69％,sensitivity 85.60％,and specificity 74.86％,respetively],and the critical value of volume percentage of solid component determined under this threshold was 8.3％.In the MIA versus IAC groups,age(P=0.017),mass(P＜0.001),and volume percentage of solid component(P＜0.001)were statistically significant;the CT threshold of-350 HU had the highest diagnostic efficacy(AUC 0.857,accuracy 78.27％,sensitivity 82.91％,and specificity 69.48％,respectively),and the critical value of volume percentage of solid component determined under this threshold was 16.9％.Conclusion The volume percentage of solid component measured based on CT density histogram analysis may be helpful in the differential diagnosis of early stage lung ade-nocarcinoma subtypes.
