Study on the correlation between carotid bifurcation geometry and atherosclerotic plaque vulnerability based on high-resolution magnetic resonance vessel wall imaging
10.3969/j.issn.1002-1671.2024.05.004
- VernacularTitle:基于高分辨率磁共振血管壁成像评估颈动脉分叉处几何形态与动脉粥样硬化斑块易损性的相关性研究
- Author:
Tongtong XU
1
;
Yumeng ZHU
;
Beiru WANG
;
Chunfeng HU
;
Hong MA
Author Information
1. 徐州医科大学附属医院放射科,江苏 徐州 221000
- Keywords:
carotid artery atherosclerosis;
vulnerable plaque;
carotid bifurcation geometry;
high-resolution magnetic resonance ves-sel wall imaging
- From:
Journal of Practical Radiology
2024;40(5):701-704,720
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between carotid bifurcation geometry and atherosclerotic plaque vulnerability using high-resolution magnetic resonance vessel wall imaging(HRMR-VWI),and to seek the potential predictor for vulnerable plaque for-mation.Methods The clinical information and imaging data of 104 patients with carotid bifurcation plaque detected by HRMR-VWI were analyzed retrospectively.Carotid bifurcation geometric parameters was measured to determine whether the carotid bifurcation plaque was vulnerable plaque,and they were divided into vulnerable plaque group(69 cases)and stable plaque group(35 cases).The difference of carotid bifurcation geometry of various groups was investigated,and the influence of common traditional risk factors to obtain independent risk factors was adjusted.Receiver operating characteristic(ROC)curve was drawn.Results Among 104 carotid artery,vulnerable plaque group had larger bifurcation angle(54.00 vs 48.80,P＜0.001),less luminal expansion(1.76 vs 1.94,P=0.002)and less outflow/inflow area ratio(0.79 vs 0.88,P＜0.001)compared with stable plaque group.After adjusting,binary logistic regres-sion indicated that bifurcation angle[odds ratio(OR)1.132 per 10° increase;95％confidence interval(CI)1.044-1.225],luminal expan-sion(OR 0.084 per 1 increase;95％CI 0.014-0.492)and outflow/inflow area ratio(OR 0.357 per 0.01 increase;95％CI 0.177-0.723)were independent risk factors of vulnerable plaque formation.Bringing them into the final model,the area under the curve(AUC)was 0.878 above the basic model(AUC=0.664).Conclusion Bifur-cation angle,luminal expansion and outflow/inflow area ratio are independently associated with vulnerable plaque formation.Carotid bifurcation geometry have the certain predictive efficiency of vulnerable plaque formation and have the incremental diagnostic value to traditional risk factors,which are expected to be effective imaging makers for the formation of vulnerable plaque.
