Evaluation of glial lymphatic system function of cerebral hemorrhage based on diffusion tensor imaging analysis along the perivascular space index
10.3969/j.issn.1002-1671.2024.05.001
- VernacularTitle:基于扩散张量成像-阿尔卑斯指数的脑出血胶质淋巴系统功能评价
- Author:
Jingyun SHA
1
,
2
;
Lulu CAI
;
Houliang ZHAO
;
Pengcheng HU
;
Kai XU
;
Chao ZHANG
Author Information
1. 徐州医科大学附属医院影像科,江苏 徐州 221006
2. 徐州医科大学,江苏 徐州 221004
- Keywords:
spontaneous intracerebral hemorrhage;
cerebral glial lymphatic system;
diffusion tensor imaging analysis along the perivascular space index
- From:
Journal of Practical Radiology
2024;40(5):689-692
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the functional changes of the glial lymphatic system in patients with spontaneous intracerebral hemorrhage(sICH)by MR diffusion tensor imaging(DTI).Methods The clinical and imaging data of 32 sICH patients(sICH group)and 31 healthy volunteers(control group)were retrospectively collected,and the diffusivity values of DTI in different direc-tions were collected from all the subjects,the diffusion tensor imaging analysis along the perivascular space(DTI-ALPS)index was calculated,the difference of DTI-ALPS index values between the sICH group and the control group was compared,the changes in the function of the glial lymphatic system in sICH patients were evaluated,and the correlation between DTI-ALPS index and clinical indi-cators in sICH patients was further analyzed.Results The DTI-ALPS index of cerebral hemispheres on the lesions side of sICH group was significantly lower than that on the unaffected side(P＜0.01,t=-5.03),and lower than that on the left side of control group(P＜0.01,t=-9.85)and the right side(P＜0.01,t=-8.80).In addition,vascular endothelial growth factor(VEGF)tes-ting was performed in 8 of the 32 patients,and the levels[(187.40±19.11)pg/mL]were significantly higher than the normal range(0-142.20 pg/mL).Conclusion Through the quantitative analysis of the DTI-ALPS index,the damage to the function of the glial lymphatic system of sICH can be reflected,and perhaps the mechanism of pathophysiological changes in the brain after sICH can be reflected from a new perspective by using MR DTI technology.
