Research progress on the impact of human milk oligosaccharides on immune system development and homeostasis in infants
10.3760/cma.j.cn101070-20240205-00076
- VernacularTitle:人乳寡糖对婴幼儿免疫系统发育和稳态的影响研究进展
- Author:
Xinyi YANG
1
;
Jiamin DONG
;
Jinling MO
;
Jingting JIANG
;
Wenting ZHANG
Author Information
1. 南通大学附属常州儿童医院儿科中心实验室，常州 213000
- Keywords:
Human milk;
Oligosaccharides;
Infants;
Immune system;
Enteric microorganism
- From:
Chinese Journal of Applied Clinical Pediatrics
2024;39(12):951-956
- CountryChina
- Language:Chinese
-
Abstract:
The gut microbiota of infants is crucial for the establishment and development of immune system tolerance and responsiveness, as well as long-term health.Breast milk, as the only recommended source of nutrition for infants under 6 months old, possesses all the necessary nutrients and functional components for their growth, development, and health promotion.Human milk oligosaccharides (HMOs), as distinctive functional components that distinguish human milk from other mammalian milk, possess natural targeting properties to reach the colorectum in its intact form and are essential for the maturation of the gut microbiota, development of the digestive system and maintenance of the immune system function in infants, providing natural protection for the digestive and immune systems of newborns.This article reviews the latest research on how HMOs affect the development of the immune system and homeostasis in infants, and focuses on the mechanism by which HMOs control the gut microbiota and influence the immune system′s response through the gut microbiota-immune axis.
