Application advance of biological agents in children with inflammatory bowel disease
10.3760/cma.j.cn101070-20231116-00360
- VernacularTitle:生物制剂在儿童炎症性肠病中的应用进展
- Author:
Biao ZOU
1
;
Shengxuan LIU
;
Sainan SHU
Author Information
1. 华中科技大学同济医学院附属同济医院儿科，武汉 430030
- Keywords:
Inflammatory bowel disease;
Biologic therapy;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2024;39(11):869-873
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease (IBD) is a chronic, nonspecific inflammatory disease of the digestive tract with unknown etiology, complicated pathogenesis and diverse clinical manifestations.Biologic therapies, particularly anti-tumor necrosis factor-α antibodies, have fundamentally changed the treatment and course of IBD in children.In recent years, more biologics have been applied to pediatric IBD.This review summarizes the application of different biologics in pediatric IBD and elaborates on the latest research progress in their mechanism of action, efficacy, safety, clinical conversion and combined application, so as to improve the optimal treatment of IBD by pediatricians.
