Renal Changes in Henoch-Schonlein Purpura with Normal Renal Function.
- Author:
Chul LEE
1
;
Pyung Kil KIM
;
Duk Jin YUN
;
In Joon CHOI
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- MeSH:
Biopsy;
Capillaries;
Cell Proliferation;
Child;
Dialysis;
Fibrinogen;
Great Britain;
Humans;
Immunoglobulin A;
Immunoglobulin G;
Immunoglobulin M;
Incidence;
Kidney Failure, Chronic;
Korea;
Natural History;
Nephritis;
Neutrophils;
Purpura;
Purpura, Schoenlein-Henoch*
- From:Journal of the Korean Pediatric Society
1980;23(9):717-723
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Henoch-Schonlenin purpura is one of the most common cause of purpura of children in Korea at present time, but well summarized report about the incidence in Korea is not submitted yet. Renal involvemnet in Henoch-Schonlein purpura nephritis is one of the important cause of end stage kidney disease in chidhood, accounting for about 15% of children who are on dialysis programs in the United Kingdom. The proportion of patients reported to have a renal involvement varies from 20% to 85%, and also the natural history from the beginning of the disease is still not well established. For these reasons, this study aims on the preliminary report on the renal changes, clinically, pathologically and immunopathologically, in three patientsof Henoch-Schonlein purpura with normal renal function. Renal biopsies show normal to minimal endocapillary cell proliferation, with a few neutrophil participation in the glomerular capillary. Mesangial matrix is partially widened in a case. Immunopathological study shows uniformly patchy focal to diffuse, spotty deposits of IgA in the mesangium, but IgG, C3, fibrinogen and IgM are lesser in degree. A case with recurrent attacks shows a focal segmental involvement by IgG, which can be considered presumably due to recurrent intermittent antigenic challenge.
