Analysis on the current situation and influencing factors of antiviral drug compliance in patients with e-antigen negative chronic hepatitis B patients who use nucleos(t)-ide analogues
10.3760/cma.j.issn.1674-2907.2017.01.019
- VernacularTitle:e抗原阴性慢性乙型肝炎患者服用核苷（酸）类似物抗病毒药物依从性现状及影响因素分析
- Author:
Yun YE
1
;
Qinfang GUO
;
Youwen TAN
Author Information
1. 212021 江苏大学附属镇江三院肝病科
- Keywords:
E-antigen;
Hepatitis B,chronic;
Nucleos(t)-ide analogues;
Drug compliance
- From:
Chinese Journal of Modern Nursing
2017;23(1):75-79
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo survey the effects of nucleos(t)-ide analogues on the drug compliance of patients with e-antigen negative chronic hepatitis B patients and its influencing factors.MethodsA retrospective survey was used to investigate consecutive patients who were hospitalized in our hospital from January 2008 to December 2009. Telephone interviews,medical inquiries,questionnaires and follow-ups were used to collect patients′ general information,which included general demographic information,medical history,and hepatitis B knowledge questionnaire.Results Follow-up data were collected from 327 compliance cases,which included 149 cases of good compliance and 178 cases of poor compliance. The compliance ratio was 45.57%. There were significant differences between good compliance group and poor compliance group in education background, economic status,insurance type,and the knowledge about hepatitis B (P<0.05). Binary Logistic regression analysis showed that high-income level,good knowledge about hepatitis B were the independent risk factors of high compliance (P<0.001).Conclusions The drug compliance of patients who use nucleos(t)-ide analogues to treat e-antigen negative chronic hepatitis B is poor,and we should strengthen the health education to improve the drug compliance of using nucleos(t)-ide analogues.
