Application of bacterial lysates in children with allergic diseases
10.3760/cma.j.cn101070-20230827-00132
- VernacularTitle:细菌溶解产物在儿童变应性疾病中的应用
- Author:
Sitong LI
1
;
Wenwen JIANG
;
Yongsheng XU
Author Information
1. 天津市儿童医院（天津大学儿童医院）呼吸科，天津 300134
- Keywords:
Allergic diseases;
Child;
Bacterial lysates;
Helper T lymphocytes 1/helper T lymphocytes 2 balance
- From:
Chinese Journal of Applied Clinical Pediatrics
2024;39(9):707-711
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of allergic diseases in children is increasing, which has become a serious public health burden.Studies have shown that the interaction between the human body and microorganisms contributes to the establishment of immune tolerance.This evidence supports the use of microbial agents for the prevention and treatment of allergic diseases.Bacterial lysates (BLs) are immunomodulators composed of inactivated extracts of a variety of bacteria associated with respiratory tract infections.BLs act on the mucosal immune system and initiate downstream immune responses by activating dendritic cells, thereby restoring T helper cell 1/T helper cell 2 balance.Relevant studies have confirmed that BLs can alleviate the clinical symptoms of allergic diseases and may play a role in primary prevention.The immunomodulatory effect of BLs is affected by many factors such as product type, administration method, and administration regimen.In clinical application, the patient′s immune status should be evaluated to avoid immune exhaustion.This review summarizes the mechanism, clinical research progress and administration regimen of BLs, in order to provide evidence for clinical application.
