Clinical analysis of 12 children with clear cell sarcoma of kidney
10.3760/cma.j.cn101070-20240117-00034
- VernacularTitle:儿童肾透明细胞肉瘤12例临床分析
- Author:
Jingjing TANG
1
;
Xueju XU
;
Songting BAI
;
Lu WANG
;
Yufeng LIU
Author Information
1. 郑州大学第一附属医院儿童医院血液肿瘤科，郑州 450052
- Keywords:
Child;
Clear cell sarcoma of kidney;
Treatment;
Prognosis
- From:
Chinese Journal of Applied Clinical Pediatrics
2024;39(9):688-690
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical features, treatment and prognosis of clear cell sarcoma of kidney (CCSK) in children.Methods:A retrospective case series study was conducted on 12 children with CCSK who were admitted to the Department of Hematology and Oncology, Children′s Hospital, the First Affiliated Hospital of Zhengzhou University from January 2014 to December 2021.The clinical characteristics, diagnosis and treatment process, and follow-up results were summarized, and the survival rate was calculated using the Kaplan-Meier method.Results:Among the 12 patients, 10 were males, and 2 were females, with the age of onset of 2.8 (1.0-5.7) years.CCSK originated from the left kidney in 6 patients and from the right kidney in 6 patients.All the patients underwent complete resection of the tumor, including 2 patients in stage Ⅰ, 4 patients in stage Ⅱ, 3 patients in stage Ⅲ, and 3 patients in stage Ⅳ; and 12 children received the corresponding chemotherapy regimen, 6 cases received radiotherapy.During the follow-up of 56 (19-94) months to December 31, 2023, 4 cases died of disease recurrence, and 8 cases survived without disease.The 5-year event-free survival rate was (62±11)%, and the 5-year overall survival rate was (72±9)%.Conclusions:Pediatric CCSK is more common in male children.The combination of radical surgery and postoperative chemoradiotherapy offers a good prognosis in the early stage, while the mortality of patients due to recurrence and distant metastasis is high.
