Advances in the use of Anakinra in febrile infection-related epilepsy syndrome

VernacularTitle:阿那白滞素在热性感染相关性癫痫综合征中的应用进展
Author: Jiechao NIU ¹ ; Yu ZHANG ; Erhu WEI ; Huaili WANG
Author Information

1. 郑州大学第一附属医院儿童医院儿童重症监护室，河南省儿童神经系统疾病临床诊治中心，河南省儿童癫痫与免疫医学重点实验室，郑州　450052
Keywords: Anakinra; Febrile infection-related epilepsy syndrome; Mechanism of action; Efficacy; Safety
From: Chinese Journal of Applied Clinical Pediatrics 2024;39(8):637-640
CountryChina
Language:Chinese
Abstract: Febrile infection-related epilepsy syndrome (FIRES) is primarily characterized by frequent focal epileptic seizures followed by generalized seizures and status epilepticus.Multiple anti-seizure drugs are ineffective in its treatment, and there′s a high mortality rate during the acute phase.Survivors often suffer from drug-resistant epilepsy and neurological dysfunctions.Anakinra is an interleukin-1 receptor antagonist.Recent studies have shown that it has potential therapeutic effects on FIRES.This article analyzes the mechanism, efficacy, safety, and future challenges of Anakinra in the treatment of FIRES, aiming to provide a basis for its application in FIRES.