Effectiveness of Timolol Malate.
- Author:
Jae Bong CHUN
1
;
Sung Eun YANG
;
Jae Myung KIM
Author Information
1. Department of Ophthalmology, College of Medicine, Kyung Hee University, Seoul, Korea.
- Publication Type:Original Article
- MeSH:
Anterior Chamber;
Cheek;
Epinephrine;
Hyperemia;
Intraocular Pressure;
Myopia;
Pilocarpine;
Rabbits;
Reducing Agents;
Timolol*
- From:Journal of the Korean Ophthalmological Society
1980;21(3):247-250
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Timolol malate, a potent beta-adrenergic antagonist, reduced intraocular pressure. The use of timolol malate ophthalmic solution was reduced intraocular pressure without pupillary alteration, alteration of anterior chamber and fluctuating myopia and hyperemia compaired with other reducing agents. We compair the effects of timolol maleate ophthalmic solution with pilocarpine and epinephirine solution in the view of the changes in intraocular pressure. We divided 30 white rabbits randomly into 3 groups, group 1 was 0.5% timolol malate, group 2 was 2% pilocarpine, and group 3 was 0.5% epinephrine. Each solution was instilled one drop on right eyes daily. and cheeked intraocular pressure after 15 minitues, 1 hour, 3 hours, 8 hours and 24 hours for 1 week duration. We evaluated the statistical significance of all changes according to the T-test and P-value. The results of observation as follow; In group I, the mean intraocular pressures was reduced 1 hour, 3 hours, 8 hours after instillation and the effect lasted 24 hours after dropping(p<0.05). In group 2, the similar result as group 1, but lasting effect was shorter than group 1 (p<0.05). In group 3, the mean intr.a.ocular pressure was reduced 8 hours after instillation (p<0.05). And compair with group 1 and group 2 we no statistical significance (p>0.05).
