A survey on the current situation of serum vitamin A and vitamin D levels among children aged 2-<7 years of 20 cities in China
10.3760/cma.j.cn112140-20230923-00216
- VernacularTitle:中国20个城市2~<7岁儿童血清维生素A和维生素D水平现况调查
- Author:
Qionghui WU
1
;
Qian CHEN
;
Ting YANG
;
Jie CHEN
;
Li CHEN
;
Xueli XIANG
;
Feiyong JIA
;
Lijie WU
;
Yan HAO
;
Ling LI
;
Jie ZHANG
;
Xiaoyan KE
;
Mingji YI
;
Qi HONG
;
Jinjin CHEN
;
Shuanfeng FANG
;
Yichao WANG
;
Qi WANG
;
Tingyu LI
Author Information
1. 重庆医科大学附属儿童医院儿童营养研究中心 国家儿童健康与疾病临床医学研究中心 儿童发育疾病研究教育部重点实验室 儿童营养与健康重庆市重点实验室，重庆 400014
- Keywords:
Vitamin A;
Vitamin D;
Child;
Multicenter study
- From:
Chinese Journal of Pediatrics
2024;62(3):231-238
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate serum vitamin A and vitamin D status in children aged 2-<7 years in 20 cities in China.Methods:A cross-sectional study was conducted. A total of 2 924 healthy children aged 2-<7 years were recruited from September 2018 to September 2019 from 20 cities in China, categorized by age groups of 2-<3 years, 3-<5 years, and 5-<7 years. The demographic and economic characteristics and health-related information of the enrolled children were investigated. Body weight and height were measured by professional staff members. The serum vitamin A and vitamin D levels were detected by high-performance liquid chromatography-tandem mass spectrometry. Chi-square test and Logistic regression were applied to analyze the association between vitamin A and vitamin D deficiency and insufficiency as well as their underlying impact factors.Results:The age of the 2 924 enrolled children was 4.33 (3.42, 5.17) years. There were 1 726 males (59.03%) and 1 198 females (40.97%). The prevalences of vitamin A and vitamin D deficiency in enrolled children were 2.19% (64/2 924) and 3.52% (103/2 924), respectively, and the insufficiency rates were 29.27% (856/2 924) and 22.20% (649/2 924), respectively. Children with both vitamin A and vitamin D deficiencies or insufficiencies were found in 10.50% (307/2 924) of cases. Both vitamin A ( χ2=7.91 and 8.06, both P=0.005) and vitamin D ( χ2=71.35 and 115.10, both P<0.001) insufficiency rates were higher in children aged 3-<5 and 5-<7 years than those in children aged 2-<3 years. Vitamin A and vitamin D supplementation in the last 3 months was a protective factor for vitamin A and D deficiency and insufficiency, respectively ( OR=0.68 and 0.22, 95% CI 0.49-0.95 and 0.13-0.40, both P<0.05). The rates of vitamin A and D insufficiency was higher in children with annual household incomes <60 000 RMB than in those with annual household incomes ≥60 000 RMB ( χ2=34.11 and 10.43, both P<0.01). Northwest and Southwest had the highest rates of vitamin A and vitamin D insufficiency in children aged 2-<7 yeas, respectively ( χ2=93.22 and 202.54, both P<0.001). Conclusions:Among 20 cities in China, children aged 2-<7 years experience high rates of vitamin A and vitamin D insufficiency, which are affected by age, family economic level, vitamin A and vitamin D supplementation, and regional economic level. The current results suggest that high level of attention should be paid to vitamin A and vitamin D nutritional status of preschool children.
