Correlation Study on Serum RLP-C Level and TyG Index in Patients with Postmenopausal Type 2 Diabetes
10.3969/j.issn.1671-7414.2024.06.034
- VernacularTitle:绝经后2型糖尿病患者血清RLP-C与TyG指数的相关性研究
- Author:
Meiling YANG
1
;
Benling HUANG
;
Caixin LI
Author Information
1. 瑞丽市人民医院检验科,云南 德宏 678600
- Keywords:
type 2 diabetes;
residual lipoprotein cholesterol;
triglyceride glucose
- From:
Journal of Modern Laboratory Medicine
2024;39(6):195-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum residual lipoprotein cholesterol(RLP-C)and triglyceride glucose(TyG)index in postmenopausal type 2 diabetes(T2DM)patients.Methods A total of 389 postmenopausal T2DM patients who attended Ruili People's Hospital from May 2019 to May 2023 were included.RLP-C and TyG index were calculated,and the study subjects were divided into the low TyG index group(n=194)and the high TyG index group(n=195)based on the median of TyG index(9.23).Differences in general clinical data and metabolism-related indexes between the two groups of patients were compared,and Spearman rank correlation was performed to explore their correlation.Single-factor and multivariate Logistic regressions were used to explore their influencing factors,and ROC curve was used to analyze their diagnostic value.Results Compared with the low TyG index group,the history of hypertension(79.49%vs 70.62%),hyperlipidemia(22.05%vs 13.40%),hemoglobin(Hb)(120.34±19.96g/L vs 114.97±21.32g/L),fasting blood glucose(FBG)[3.97(3.03,5.10)mmol/L vs 3.64(2.99,4.74)mmol/L],total cholesterol(TC)[5.00(4.40,5.95)mmol/L vs 4.36(3.78,5.30)mmol/L],triacylglycerol(TG)[2.11(1.60,3.00)mmol/L vs 1.20(0.91,1.54)mmol/L],low-density lipoprotein(LDL-C)[[2.99(2.43,3.93)mmol/L vs 2.71(2.13,3.38)mmol/L],non-high-density lipoprotein(nonHDL-C)[3.94(3.22,4.82)mmol/L vs 3.15(2.53,3.94)mmol/L]and RLP-C concentration[0.76(0.52,1.08)mmol/L vs 0.44(0.29,0.59)mmol/L]of the high TyG index group were higher,while high-density lipoprotein(HDL-C)concentration was lower,and the differences were statistically significant(x2=4.09,4.99;t=-2.56;Z=-2.34,-5.15,-12.08,-3.04,-6.23,-9.15,-3.99,all P<0.05).Spearman correlation analysis showed that TyG in all samples was positively correlated with TC,TG,LDL-C,RLP-C and nonHDL-C(r=0.304,0.769,0.179,0.386,0.571,all P<0.001),but was negatively correlated with HDL-C(r=-0.306,P<0.001).The correlations between TyG and TC,LDL-C in the high TyG index group were not significant(all P>0.05).Single-actor logistic regression analysis showed that history of hypertension,hyperlipidemia,HDL-C,LDL-C,and RLP-C were the factors influencing TyG levels[OR(95%CI)=1.61(1.01～2.57),1.83(1.07～3.12),0.28(0.14～0.54),1.21(1.02～1.43),17.58(8.11～38.11),all P<0.05],while the multivariate regression analysis showed that only RLP-C was an independent risk factor for elevated TyG[OR(95%CI)=13.17(5.71～30.37),P<0.001).ROC curves showed that the AUC(95%CI)for the diagnosis of TyG index elevation by RLP-C was 0.768(95%CI:0.721～0.816),with the cutoffvalue of 0.59 mmol/L.The sensitivity and specificity were 69.71%and 75.77%,respectively.Conclusion RLP-C is an independent risk factor for elevated TyG in postmenopausal T2DM patients,which has some clinical value in predicting insulin resistance.
