Correlation between the Serum Leptin Level and the Expression of Leptin in Stomach Cancer Patients.
10.5230/jkgca.2008.8.4.176
- Author:
Ji Hyun KIM
1
;
Hun JUNG
;
Kyong Hwa JUN
;
Sung Keun KIM
;
Hyung Min CHIN
;
Ji Han JUNG
;
Wook KIM
;
Hae Myung JEON
;
Cho Hyun PARK
;
Seung Man PARK
;
Woo Bae PARK
;
Keun Woo LIM
;
Seung Nam KIM
Author Information
1. Department of Surgery, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea. dkkwkh@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Stomach cancer;
Leptin;
Leptin receptor
- MeSH:
Adenocarcinoma;
Body Weight;
Cell Proliferation;
Eating;
Energy Metabolism;
Epithelial Cells;
Humans;
Immunoassay;
Leptin;
Receptors, Leptin;
Stomach;
Stomach Neoplasms
- From:Journal of the Korean Gastric Cancer Association
2008;8(4):176-181
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The adipocyte-derived cytokine leptin plays a major role in the control of stable body weight by suppressing food intake and increasing energy metabolism. Leptin regulates the cell proliferation of various epithelial cells and it may be involved in the promotion of cancer. Leptin and its receptor are highly expressed in gastric adenocarcinoma, but the association between the serum leptin level and the tissue expression of leptin is uncertain. We evaluated the serum leptin level and the expressions of leptin and leptin receptor in gastric cancer, and we explore the possible mechanism and role of leptin in the carcinogenesis of gastric cancer. MATERIALS AND METHODS: 72 carcinomas that were curatively resected at our hospital from October 2005 to March 2007 were included in this study. By immunoassay and immunohistochemical staining, we evaluated the serum leptin level and the expressions of leptin and its receptor, and we analyzed their relationship together with the clinicopathological variables. RESULTS: The serum leptin level was increased as the patient's BMI increased and it was decreased in H. pylori infected patients. The expression of leptin was increased as the TNM stage increased (P=0.014), and the expression of leptin receptor in the intestinal type gastric adenocarcinoma was higher than that in the diffuse type gastric adenocarcinoma (71.4% vs 28.6%, respectively, P=0.033). CONCLUSION: There was no significant correlation between the serum leptin level and expression of leptin in gastric cancer patients. The expression of leptin was associated with the TNM stage, but its role in the pathogenesis of gastric cancer has to be elucidated.
