Advancements in Latest Fusion Gene Detection Methods
10.3969/j.issn.1671-7414.2024.05.038
- VernacularTitle:融合基因检测方法的最新研究进展
- Author:
Zhiyuan ZHANG
1
;
Zhi ZHENG
;
Xiaoyi TIAN
Author Information
1. 中国医学科学院基础医学研究所/北京协和医学院基础学院生物化学与分子生物学系,北京 100005
- Keywords:
fusion gene;
next-generation sequencing;
liquid biopsy
- From:
Journal of Modern Laboratory Medicine
2024;39(5):205-212
- CountryChina
- Language:Chinese
-
Abstract:
Fusion genes are new sequences formed by the recombination of two or more gene fragments in the genome that play an important biological role and have clinical significance in the proces of tumorigenesis and development.The detection of fusion genes can provide important guidance for early diagnosis,risk stratification and targeted therapy of tumors.Traditional fusion gene detection methods dominate clinical applications,but have limitations such as low sensitivity,high cost or technical complexity,making them difficult to apply on a large scale.Fortunately the rapid advancements of new biotechnology,a series of new fusion gene detection methods are gradually emerging,providing new alternatives for fusion gene detection.This article reviews traditional fusion gene detection methods and the sequencing technologies developed in recent years,aiming to provide ideas for the detection of fusion genes and guidance for the diagnosis and precise treatment of related diseases.
