Study on the Clinicopathological Characteristics and Prognostic Value of the Expression of OTUD5 and RNF186 in Non-muscle Invasive Bladder Cancer
10.3969/j.issn.1671-7414.2024.05.014
- VernacularTitle:非肌层浸润性膀胱癌组织中OTUD5和RNF186表达与临床病理特征的关系及预后价值研究
- Author:
Nan WU
1
;
Liru SUN
;
Yadong LI
;
Wenjun LIU
Author Information
1. 唐山市中医院泌尿外科,河北唐山 063000
- Keywords:
non-muscle invasive bladder cancer;
domain protein ubiquitin 5;
ring finger protein 186;
clinicopathological characteristics
- From:
Journal of Modern Laboratory Medicine
2024;39(5):75-79,101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of domain protein ubiquitin 5(OTUD5)and ring finger protein 186(RNF186)in non-muscle invasive bladder cancer(NMIBC)and their relationship with clinicopathological characteristics and prognostic value.Methods A total of 106 NMIBC patients admitted to Tangshan Traditional Chinese Medicine Hospital from January 2019 to January 2020 were collected.OTUD5 and RNF186 expression in NMIBC cancer tissue and para-cancer tissue were detected by immunochemistry.The differences between OTUD5 and RNF186 expressions in NMIBC cancer tissues with different clinical and pathological characteristics were compared.Kaplan-Meier curve analysis(Log Rank test)was used to analyze the impact of OTUD5 and RNF186 expression on progression free survival of NMIBC.COX regression model analysis was used to analyze factors affecting progression free survival in NMIBC patients.Results The positive rates of OTUD5(62.26％)and RNF186(66.04％)in NMIBC cancer tissue were higher than those in adjacent tissues(11.32％,8.49％),with significant differences(x2=59.146,75.079,all P＜0.05).There was a significant positive correlation between OTUD5 and RNF186 expressions in NMIBC cancer(r=0.659,P＜0.05).The positive rates of OTUD5(72.97％,84.21％)and RNF186(77.03％,86.84％)in T1 stage and high-grade NMIBC cancer tissues were higher than those in Ta/Tis stage(37.50％,50.00％)and low-grade cancer tissues(40.63％,54.41％),and the differences were significant(x2=11.964,13.199;12.143,11.431,all P＜0.05).The 3-year cumulative progression free survival rate of patients in the OTUD5 positive group(40.91％)and RNF186 positive group(45.70％)were lower than that in the OTUD5 negative group(90.00％)and RNF186 negative group(86.11％)(Log Rank test x2=24.710,14.586,all P＜0.05).OTUD5 positive(OR=1.446,95％CI:1.086～1.925),RNF186 positive(OR=1.579,95％CI:1.132～2.024),Tumor TNM stage T1(OR=1.582,95％CI:1.219～2.054)and high pathological grade(OR=1.570,95％CI:1.188～2.074)were independent risk factors affecting progression free survival in NMIBC patients(all P＜0.001).Conclusion The increased expression of OTUD5 and RNF186 in cancer tissue of NMIBC patients are related to tumor TNM staging and pathological grading and are independent risk factors affecting the prognosis of NMIBC patients.
