Predictive Value of Serum IRF5 and SOCS-3 Expression Levels in Colorectal Cancer Patients for Postoperative Intestinal Obstruction
10.3969/j.issn.1671-7414.2024.05.013
- VernacularTitle:结直肠癌患者血清IRF5和SOCS-3表达水平对术后肠梗阻的预测价值
- Author:
Zhen WANG
1
;
Linyun CHEN
;
Lin WANG
;
Feng LIU
Author Information
1. 沧州市人民医院内镜诊疗中心,河北沧州 061000
- Keywords:
colorectal cancer;
postoperative intestinal obstruction;
interferon regulatory factor-5;
suppressors of cytokine signaling-3
- From:
Journal of Modern Laboratory Medicine
2024;39(5):69-74
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe serum interferon regulatory factor-5(IRF5)and suppressors of cytokine signaling-3(SOCS-3)levels in patients with colorectal cancer,and investigate predictive value of their levels on the occurrence of postoperative intestinal obstruction in patients.Methods A total of 100 colorectal cancer patients who attended the Cangzhou People's Hospital from January 2022 to March 2023 were selected as the study subjects.According to whether the patient experienced intestinal obstruction after surgery,they were divided into the intestinal obstruction group(n=14)and the control group(n=86).Preoperative serum levels of IRF5 and SOCS-3 were detected by enzyme-linked immunosorbent assay(ELISA).Factors influencing the occurrence of postoperative intestinal obstruction in colorectal cancer patients were analyzed by Logistic regression.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum IRF5 and SOCS-3 levels on the occurrence of postoperative intestinal obstruction in colorectal cancer patients.Results Serum IRF5 levels in the intestinal infarction group(0.68±0.09ng/ml)were lower,but serum SOCS-3 levels in the intestinal infarction group(97.23±15.94pg/ml)were higher than in the control group(0.89±0.12ng/ml,75.03±12.46pg/ml),with significant differences(t=6.257,5.937,all P＜0.05).SOCS-3 was an independent risk factor(OR=2.197,95％CI:1.167～4.138,P＜0.05),and 1RF5 was an independent protective factor(OR=0.823,95％CI:0.705～0.961,P＜0.05)affecting the occurrence of postoperative bowel obstruction in patients with colorectal cancer.The areas under the curve(AUC)of serum IRF5,SOCS-3,and the combination of the two for the diagnosis of postoperative intestinal obstruction in colorectal cancer patients were 0.852(95％CI:0.767～0.915),0.817(95％CI:0.727～0.887)and 0.953(95％CI:0.891～0.985),respectively.The combined diagnostic efficacy of the serum IRF5,SOCS-3 was higher than the efficacy of the test alone,with significant differences(Z=1.967,2.034,P=0.049,0.042).Conclusion Serum IRF5 levels are reduced,but SOCS-3 levels are increased in patients with colorectal cancer.Both have a predictive value for the development of postoperative bowel obstruction in patients with colorectal cancer.
