The Diagnostic Utility of PET-CT for the Preoperative Evaluation of Lymph Node Metastasis in Gastric Cancer Patients.
10.5230/jkgca.2008.8.4.250
- Author:
Sung Hyuk PARK
1
;
Min Su CHO
;
Hoon RYU
;
Keum Seok BAE
;
Ik Yong KIM
;
Dae Sung KIM
Author Information
1. Department of Surgery, Wonju Christchan Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea. daeskim@yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Gastric cancer;
Lymph node metastasis;
PET-CT
- MeSH:
Electrons;
Gastrectomy;
Humans;
Lymph Node Excision;
Lymph Nodes;
Neoplasm Metastasis;
Sensitivity and Specificity;
Stomach Neoplasms
- From:Journal of the Korean Gastric Cancer Association
2008;8(4):250-255
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to assess the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for detecting the lymph node (LN) metastasis of gastric cancer. MATERIALS AND METHODS: 119 patients (M:F=89:30; mean age: 64) with gastric cancer were referred for preoperative FDG-PET/CT scanning and spiral enhanced abdominal pelvic CT from June 2006 to July 2008, and these were the subjects of our study. All the patients underwent curative radical gastrectomy and lymph node dissection. A final diagnosis was made for all the patients by the histology of the surgical specimens. RESULTS: Both PET/CT and enhanced CT showed similar sensitivity for detecting regional lymph node metastasis (32.6% vs 39.5%, respectively). PET/CT was more accurate than enhanced CT for detecting regional lymph node metastasis (67.2% vs 63.0%, respectively), and PET/CT showed better specificity (86.8% vs 76.3, respectively) and a better positive predictive value (PPV) (58.3% vs 48.6%, respectively). PET/CT showed better specificity (98.0% vs 88.2%, respectively) and accuracy (79.4% vs 73.9%, respectively) than enhanced CT for detecting early gastric cancer. PET/CT showed better specificity (64.0% vs 52.0%, respectively), a better PPV (60.9% vs 57.1%), a better negative predictive value (NPV) (48.5% vs 46.4%, respectively) and better accuracy (53.6% vs 51.8%, respectively) than enhanced CT for detecting advanced gastric cancer. CONCLUSION: FDG-PET/CT is more usefulness than enhanced CT for making the preoperative diagnosis of regional LN metastases from gastric cancers.
