Correlation between the Expression Levels of Serum CTRP9 and sCD146 and Coronary Artery Lesions in Children with Kawasaki Disease
10.3969/j.issn.1671-7414.2024.03.029
- VernacularTitle:川崎病患儿血清CTRP9和sCD146水平表达与冠状动脉损伤的相关性研究
- Author:
Yueyue LI
1
;
Li TANG
;
Mingyue ZHU
Author Information
1. 重庆市开州区人民医院 内科,重庆 405400
- Keywords:
Kawasaki disease;
C1q/tumor necrosis factor related protein 9;
soluble CD146;
coronary artery lesions
- From:
Journal of Modern Laboratory Medicine
2024;39(3):170-175
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum C1q/tumor necrosis factor related protein 9(CTRP9)and soluble CD146(sCD146)levels and coronary artery lesions(CAL)in children with Kawasaki disease(KD).Methods A total of 116 children with KD admitted to the People's Hospital of Kaizhou District,CQ from October 2020 to February 2023 were selected as the study subjects(KD group).According to the ultrasound diagnosis results,children with KD were grouped into CAL group(n=40)and non CAL group(n=76).According to the severity of CAL,children with KD in the CAL group were separated into mild group(n=14),moderate group(n=18)and severe group(n=8).Enzyme linked immunosorbent assay(ELISA)was applied to measure serum levels of CTRP9 and sCD146.The differences in serum levels of CTRP9 and sCD146 in control group,CAL group,non CAL,and children with different severity of CAL were compared.Multiple Logistic regression was applied to analyze the factors affecting the occurrence of CAL in children with KD.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum CTRP9 and sCD146 levels for the occurrence of CAL in KD children.Results Compared with the control group,the serum CTRP9 level in the KD group was decreased(3.27±0.27ng/ml vs 3.79±0.91ng/ml),while the sCD146 level was increased(191.28±50.39 ng/ml vs 143.97±38.29 ng/ml),with significant differences(t=5.900,8.051,all P＜0.05).The serum CTRP9 level in the CAL group was lower than that in the non CAL group(3.01±0.23ng/ml vs 3.41±0.29 ng/ml),but the sCD146 level was higher than that in the non CAL group(232.18±59.37 ng/ml vs 169.76±45.66 ng/ml),with significant differences(t=7.557,6.294,all P＜0.05).Compared with the mild group,the serum CTRP9 level in the moderate and severe groups was decreased(q=3.277,6.281),with sCD146 level increased(q=3.154,5.551),the serum CTRP9 level in the severe group was lower than that in the moderate group(q=3.845),with sCD146 level was higher than that in the moderate group(q=3.145),and the differences were statistically significant(all P＜0.05).The results of multivariate logistic regression analysis showed that white blood cell count(WBC),erythrocyte sedimentation rate(ESR),C reactive protein(CRP),CTRP9 and sCD146 were all influencing factors for the occurrence of CAL in children with KD(all P＜0.05).The results of ROC curve showed that the AUCs of CTRP9 and sCD146 separately predicted the occurrence of CAL in KD children were 0.781 and 0.782,with sensitivity of 82.5％and 67.5％,and specificity of 52.2％and 55.7％,respectively.The AUC for the combined diagnosis of CAL in children with KD was 0.889,with sensitivity and specificity of 97.5％and 65.9％,respectively.Conclusion Serum CTRP9 and sCD146 were influencing factors for the occurrence of CAL in children with KD,and the level of CTRP9 was decreased,while sCD146 was increased in the serum of children with CAL.The combination of the two can effectively predict the occurrence of CAL in children with KD.
