Transient infantile hypertriglyceridemia caused by GPD1 deficiency: report of two cases and literature review
10.3760/cma.j.cn112140-20200411-00375
- VernacularTitle:GDP1基因缺陷导致婴儿暂时性高甘油三酯血症二例并文献复习
- Author:
Xinbao XIE
1
;
Mengping LI
;
Jianshe WANG
Author Information
1. 复旦大学附属儿科医院肝病中心，上海201102
- Keywords:
Hypertriglyceridemia;
Child;
Genes;
Disease attributes
- From:
Chinese Journal of Pediatrics
2020;58(11):923-927
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical phenotype and genotype of transient infantile hypertriglyceridemia (HTGTI).Methods:The clinical data of two HTGTI children, diagnosed at Children′s Hospital of Fudan University from July 2019 to January 2020, were collected and analyzed retrospectively. The literature up to 25th January 2020 were searched in PubMed, CNKI and Wanfang databases with the key words of "hypertriglyceridemia" and "glycerol phosphate dehydrogenase-1 (GPD1)".Results:Two children, including a 5-month-old female and a 13-month-old male, who presented with hepatomegaly, hypertriglyceridemia, transaminase elevation and hepatic steatosis, were admitted to the hospital. Gene detection found compound heterozygous variation of GPD1. After a low-fat diet with enriched medium-chain fatty acids, their plasma triglyceride level were significantly decreased, and finally normalized in case 2. Literature review found 17 patients with GPD1 gene variation reported in 5 papers, including 16 HTGTI cases and one case of different phenotype. Most of the cases presented with hepatomegaly, hypertriglyceridemia and transaminase elevation, while some had developmental retardation, splenomegaly, hypoglycemia, obesity and insulin resistance. The c.361-1G>C was the most common variation of GPD1.Conclusions:HTGTI caused by GPD1 deficiency is mainly manifested with hepatomegaly, hypertriglyceridemia, transaminase elevation as well as hepatic steatosis and fibrosis. The most common variation of GPD1 is c.361-1G>C.
