Primary Study on Heart Rate Variability of Non-linearDynamics in Patients with Coronary Artery Disease and Diabetes

VernacularTitle:冠心病和糖尿病人心率变异性非线性动力学初探
Author: Zheng XU ¹ ; Hui ZHANG ; Jiguang GE ; Qiuping XU
Author Information

1. 浙江大学
From: Journal of Biomedical Engineering 2001;18(2):316-319
CountryChina
Language:Chinese
Abstract: This is a comparative study on the non-linear dynamics between 30 healthy controls and three groups of patients with single coronary artery disease(n=20), multi-coronary disease(n=8), and diabetic patients with diabetic autonomic neuropathy (DAN)(n=18), respectively.We selected and adopted six quantity indices of dispersed-dot plot,including the area of plot (SQ), long-axis (LA), short-axis (SA), the angle of long-axis and short-axis (ALS), vector length index (VLI) and vector angle index (VAI), and Kolmogorov entropy and fractal dimension. We found that the non-linear indices in healthy control had obvious day-to-night change, while the change in coronary artery disease patients decreased and disappeared in diabetics. By the findings that both coronary artery disease patients and diabetic patients had the turbulence of vegetal nerve system, we concluded that the vegetal nerve activity might be an important factor in heart non-linear dynamics. And marked differences in the non-linear indices were seen between the normal control, the single-vessel, multi-vessel coronary artery disease patients, and the diabetic patients, thus suggesting that these indices may be used in clinical practice.