Plasma 5-Hydroxytryptamine Concentration and Its Correlation with Psychopathology in Patients with Irritable Bowel Syndrome.
- Author:
Seon Young PARK
1
;
Min Ho PARK
;
Kyoung Won YOON
;
Sung Bum CHO
;
Wan Sik LEE
;
Chang Hwan PARK
;
Hyun Soo KIM
;
Sung Kyu CHOI
;
Jong Sun REW
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. jsrew@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Irritable bowel syndrome;
5-hydroxytryptamine;
Psychopathology
- MeSH:
Checklist;
Fasting;
Gastrointestinal Motility;
Humans;
Irritable Bowel Syndrome;
Plasma;
Psychopathology;
Sensation;
Serotonin
- From:Gut and Liver
2009;3(1):26-30
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) is a biopsychosocial disorder. 5-Hydroxytryptamine (5-HT) plays a crucial role in the control of gastrointestinal motility, sensation, and secretion. This study investigated changes in platelet-depleted plasma 5-HT and their correlation with psychopathology in IBS patients and healthy subjects. METHODS: This study involved 21 subjects with IBS and 13 healthy subjects. Fasting and 1-hr postprandial plasma 5-HT concentrations were measured. The SCL-90R symptom checklist was used for the assessment of current psychological symptoms. RESULTS: Fasting and postprandial plasma 5-HT concentrations were significantly higher in IBS patients (15.11+/-13.51 ng/mL and 16.31+/-14.21 ng/mL, respectively) than in healthy subjects (5.55+/-4.14 ng/mL and 6.25+/-4.82 ng/mL, respectively; p<0.05). There were no significant changes between fasting and 1-hr postprandial 5-HT concentration in IBS subtypes and healthy subjects. Scores on all SCL-90R subscales except for the interpersonal-sensitivity subscale were significantly higher in IBS patients than in healthy subjects. No correlation was found between SCL-90R items and platelet-depleted plasma 5-HT concentration. CONCLUSIONS: 5-HT might play a critical role in IBS, and psychopathological factors are correlated with IBS.
