The Cytotoxic Effects of the Adriamycin Magnetic Albumin Microspheres Combined with External Magnetic Fields on the Malignant Tumor Cells

VernacularTitle:阿霉素磁性蛋白微球联合外磁场对恶性肿瘤细胞的毒性试验
Author: Kaixiong TAO ¹ ; Daoda CHEN ; Yuan TIAN ; Zaide WU
Author Information

1. Union Hospital Tongji Medical College Huazhong University of Science and Technology
From: Journal of Biomedical Engineering 2001;18(2):223-226
CountryChina
Language:Chinese
Abstract: This study sought to assess the inhibitory effects of the adriamycin magnetic albumin microspheres(ADM-MAMs) on Walker-256 mal ignant tumor cells in vitro induced by the permanent magnetic fields.T he cultured Walker-256 cells were divided into three groups:the group o f ADM-MAMs combined with magnetic fields, the group of AMD-MAMs without magnetic fields, and ADM group.The growth states of the cells were obse rved and photographed under the inverted microscope.The inhibitory rates(IR) were assayed by the modified MTT colorimetric method.The resu lts showed that the IR of the ADM-MAMs group were similar to those of the ADM group (P＞0.05),but the group of ADM-MAMs combined with magnetic field s had obviously higher IR and significent changes of the cells′ shapes.These findings indicate that the anticancer effect of ADM-MAMs on malignant tumor cells is similar to that of ADM,and such effect can be increased by the combined use of ADM-MAMs and external magnetic fields.