Manufacture and Study of Porous Poly(l-lactic acid)(PLLA)/β-tricalcium Phosphate (β-TCP) Composite
10.3321/j.issn:1001-5515.2001.02.003
- VernacularTitle:聚L-乳酸（PLLA）/β-磷酸三钙（β-TCP）多孔复合材料的制备及其性能研究
- Author:
Rui CHEN
1
;
Huaiqing CHEN
;
Jun HAN
;
Dali ZHOU
;
Changqiong ZHENG
Author Information
1. 华西医科大学
- From:
Journal of Biomedical Engineering
2001;18(2):177-180,184
- CountryChina
- Language:Chinese
-
Abstract:
A promising alternative to supply bone substitutes is to develop living tissue substitutes based on biodegradable materials, which is called bone tissue engineering. One of the research high-lights of bone tissue engineering is to design and manufacture scaffolds for cell attaching, migrating, and proliferating. A process which consists of a solvent casting stage, a compression molding stage and a leaching stage has been used to fabricate macroporous composites of poly(l-lactic acid)(PLLA) and β-tricalcium phosphate (β-TCP). The effects of the weight fraction of porogen-NaCl, of the weight ratio of PLLA to β-TCP and of the diameters of β-TCP on the porosities, the average pore diameters and the compressive yield strength and compressive modulus have been studied. The results showed that the porosities and the average pore diameters increased and the compressive yield strength and modulus decreased when the weight fraction went from 50% to 90%. The compressive yield strength and compressive modulus could be improved by changing the weight ratio of PLLA to β-TCP and the diameters of β-TCP in low-porosity composites (lower than 70%). But high-porosity composites (90%) were not reinforced by changing the weight ratio.
