Kinetics of In Vitro Drug Release from Chitosan and N-alkyl Chitosan Membranes
10.3321/j.issn:1001-5515.2001.01.039
- VernacularTitle:壳聚糖膜及其改性膜的药物释放动力学研究
- Author:
Mingchun LI
1
;
Meihua XIN
;
Qong WANG
;
Kangde YAO
Author Information
1. Huaqiao University
- From:
Journal of Biomedical Engineering
2001;18(1):154-155
- CountryChina
- Language:Chinese
-
Abstract:
By using the so-called “lag-time” method, we studied the effect of membrane thickness(h), initial drug concentration(Co) and flow rate(V) on the difusion coefficient(D) of model drug in membranes. The expe riment indica tes that D increases as hand vincrease; D Keeps constant when C0 changes; Un den the same condition, the D value of N-alkyl chitosan membrane is bigger than that of pure chitosan membrane.
