Effect of Estrogen on Hemodynamics and Vascular Remodeling with Takayasu Arteritis
- VernacularTitle:雌激素对血流动力学及多发性大动脉炎血管重构的影响
- Author:
Zhipeng HONG
1
;
Fuzhen CHEN
;
Weiguo FU
;
Xing XU
Author Information
1. Kunming Medical College
- From:
Journal of Biomedical Engineering
2001;18(1):22-25
- CountryChina
- Language:Chinese
-
Abstract:
This study utilized Takayasu arteritis (TA) mo del to do the experiment in order to observe the remodeling of arterial geometry . Plasma estrogen, progesterone and products of nitrous oxide(NO2- and NO3 -) were examined. Qualitative analyses of maximum (MAX), minimum (MIN) and mea n (MEAN) velocity of blood flow, resistant index (PI), pulsatile index (PI)， an d shear stress (SS) of abdominal aorta were performed.The results showed that pl asma estrogen, progesterone and products of nitrous oxide were respectively 1137 .80±189.30pg*ml-1，14.10±1.61μg*ml-1 and 195.78±53.01 μ mol*L-1 in experiment group, whereas in control group, they were 34.74± 10.20pg*ml-1，2.60±1.83μg*ml-1 and 12.16±3.28μmol*L- 1 respectively, P＜0.01. In comparison of hemodynamic parameters of abdo minal aorta, the MAX and MIN of experiment group were profoundly higher than tho se of control group. SS increased markedly in experiment group. The observation of arterial remodeling in vitro found wall thickening. The thickness of abdomina l aortic wall and inside diameter of vessel cavity ratio (h/Di) was 0.6145±0. 1654 in experiment group and 0.2151±0.0266 in control group, P＜0.01. Th e arterial collagen content in experimental group was significantly higher than that in control group. Hyperestrinemia gives rise to a series of hemodynamic al terations, influences vessel remodeling along with TA, and finally results in a rterial stenosis, occlusion or aneurysms due to the constitutional composition o f vascular wall reforming.
