Research on Fibrotic Effect of Ni-Ti and 317L Alloys in Esophagus

VernacularTitle:Ni-Ti、317L合金在食管局部的致纤维化研究
Author: Xinjian WAN ¹ ; Zhaoshen LI ; Guoming XU ; Renpei WU ; Wei ZHANG ; Xiaohua MAN
Author Information

1. Changhai Hospital Second Military Medical University
From: Journal of Biomedical Engineering 2001;18(1):12-15
CountryChina
Language:Chinese
Abstract: This study was conducted to examiune the fibrotic effect of Ni-Ti and 317L al loys in esophagus.The extract fluid from Ni-Ti,317L alloys was made according t o the ASTM standards of U.S.A. The Fb of esophageal scar was cultured primarily ，then incubated with alloy abstract fluid. The proliferating activity of Fb was measured by MTT at 4, 24, 48, 72 hours in the course of culturing. The esophagu s embedding test of Ni-Ti,317L alloys was made according to ASTM standards of U .S.A.The tissue around the alloys was taken at weeks 2 and 12，and the pathologi c changes were analysed. The results showed that Ni-Ti,317L extract could depre ss the proliferating function of Fb gently，and the depressing action increased gradually with the culturing time.The result of embedding test was in accord wit h the ASTM standards of U.S.A completely; the fibrotic membrane around the NiTi, 317L alloys became thinner with embedding time. These findings suggested that t he scattering composition of Ni-Ti,317L in body fluid might not activate the pr oliferating and secreting function of Fb，and the two alloys could not lead to f ibrosis of esophagus aroun them.