Effects of modified Leuven′s adjustment on blood glucose variability in patients with severe traumatic brain injury
10.3760/cma.j.issn.1674-2907.2016.27.018
- VernacularTitle:Leuven调节的改良方案对重型颅脑损伤患者术后血糖变异的影响
- Author:
Chang′e HE
1
;
Yumei ZHANG
;
Hanwen YAN
;
Xiaojun ZHANG
;
Jie SHENG
;
Aiping WU
;
Shufeng GONG
;
Xiaoling NI
;
Xiaohong WANG
Author Information
1. 212300 江苏省丹阳市人民医院急诊科
- Keywords:
Brain injury;
Blood glucose variability;
Hyperglycemia;
Hypoglycemia
- From:
Chinese Journal of Modern Nursing
2016;22(27):3921-3924
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of two different methods on the blood glucose variability (BGV) of patients with traumatic brain injury (TBI) who had performed the surgery.Methods A total of 100 patients with TBI after the surgery, who were admitted at intensive care unit ( ICU) from June 2013 to July 2014, were randomly assigned to the observation group ( n=50) and the control group ( n=50) . Patients in the control group received the routine treatment to adjust the BVG. Patients in the observation group received the modified Leuven′s adjustment processes. Blood glucose was continuously monitored in 5 days and all the data include mean blood glucose, incidence of hypoglycemia (level of blood glucose≤3.2 mmol/L), blood glucose standard deviation (SD), mean amplitude of glycemic excursions (MAGE) and glucose lability index (GLI) were performed statistical analysis. Results Mean blood glucose was stable in 5 days after operation in two groups (P>0.05). The blood glucose SD, MAGE and GLI in the observation group among the first 2 days [1st day:(4.7±1.2), (0.86±0.41), (255.9±213.7);2nd day:(4.0±1.7), (0.63±0.38), (202.7±163.5)] was higher than the control group [1st day:(1.1±0.68), (0.51±0.25), (112.7±92.8); 2nd day: (1.2±0.44), (0.41±0.17), (93.1±72.7)], and the difference was statistically significant (P<0.05). In the last 3 days, these data between two groups all fallen and the difference was insignificant ( P>0. 05 ) . The incidence of hypoglycemia in the observation group was lower than that of the control group in the 1st day ( P<0.05) . In the last 4 days, the data in two groups fell (P>0.05).Conclusions The modified Leuven′s adjustment processes has characteristics of early adjustment, accessible and operate simply. It is better than the routine adjustment processes in the BGV control at the early stage.
