Exploring the Core Medication and Efficacy Evaluation of Hypoxic Pulmonary Hypertension Based on the Traditional Chinese Medicine Inheritance Assistance Platform
- VernacularTitle:基于中医传承辅助平台探究低氧型肺动脉高压的核心用药及药效评价
- Author:
Zhengwei DONG
1
;
Min ZHANG
;
Yun DING
;
Zuoying XING
;
Rui YU
;
Mengyi ZHAO
;
Guanwei FAN
;
Yongxia WANG
;
Mingjun ZHU
Author Information
- Keywords: Hypoxic pulmonary hypertension; Core medication; Data mining; Traditional Chinese medicine inheritance assistance platform; Medicinal efficacy evaluation; Salvia miltiorrhiza
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(8):2016-2022
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the core drugs of traditional Chinese medicine(TCM)for the treatment of hypoxic pulmonary hypertension(HPH),and to verify the drug efficacy by hypoxia combined with Su5416(Hypoxia+Su5416,HySu)-induced PH mouse model.Methods Relevant literatures on TCM treatment of HPH in China Knowledge Network,Wanfang,Weipu were collected,screened and set up a database through the nerf criteria,and inputted into the software of traditional Chinese medicine inheritance assistance platform(V2.5)for the excavation of medication law.The HySu-PH mouse model was established,and the core drugs were evaluated for drug efficacy through force exhaustion exercise running table,blood oxygen saturation,right ventricular pressure,and right heart hypertrophy index test.Results The 102 relevant formulas for the treatment of HPH were screened,involving a total of 158 traditional Chinese medicines,and the top 5 drug frequencies were Salvia miltiorrhiza,Rhizoma Chuanxiong,Astragalus membranaceus,Draba hebecarpa,and Angelica sinensis,with the highest use of blood-activating and blood-stasis removing drugs,and deficiency-tonifying drugs in the categories of drugs used,and Salvia miltiorrhiza was the core drug used.HySu-PH mouse models were constructed and given 2 weeks of treatment with the danshen preparation Danshen injection.Danshen injection significantly elevated body weight(P<0.01),oxygen saturation(P<0.05),displacement of exhaustion(P<0.01),and duration of exhaustion(P<0.05),and lowered the right ventricular systolic blood pressure(P<0.01)and the right cardiac hypertrophy index(P<0.01).Conclusion Salvia miltiorrhiza is a core drug for the treatment of HPH,and the danshen preparation Danshen injection can effectively treat HySu-PH.
