Clinical Research of BaoShenTongLuo on Diabetic Kidney Disease with Qi Yin Deficiency and Blood Stasis
- VernacularTitle:保肾通络方对糖尿病肾脏病气阴两虚兼血瘀证的临床疗效观察
- Author:
Fangqiang CUI
1
;
Yuan MENG
;
Yuefen WANG
;
Zhen CAI
;
Xincan JIANG
;
Wenjing ZHAO
Author Information
- Keywords: Diabetic kidney disease; BaoShenTongLuo decoction; Qiyinliangxuxueyu; Inflammatory factors; Clinical research
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(7):1840-1846
- CountryChina
- Language:Chinese
- Abstract: Objective To observe the effect of BaoShenTongLuo(BSTL)Decoction on diabetic kidney disease and serum inflammatory factors of DKD.Methods A total of 80 DKD patients were collected from patients of Beijing Hospital of Traditional Chinese Medicine.The patients were then randomly divided into control group and treatment group.Patients in control group were received with basic treatment.Patients in treatment group were received with BSTL decoction along with basic treatment.The treatments were lasted for 3 months.Scr,BUN,UACR,24 h proteinuria,MCP-1,TGF-β 1,CRP,IL-6 and TNF-a were detected.Clinical symptom scores of patients in two groups were calculated.Results The total effective rate of treatment group was higher than that in the control group(P<0.05).The scores of TCM symptoms were lower in the treatment group than those in the control group after treatment(P<0.01).Compared with control group,24 h proteinuria,UACR,Scr and BUN was significantly decreased in treatment group after the treatment(P<0.01).After the treatment,the level of MCP-1,TGF-β1,CRP,IL-6 and TNF-α were significantly decreased in treatment group compared with control group(P<0.01).Conclusion BSTL can significantly decrease proteinuria and improved renal function in DKD.More importantly,BSTL can significantly decrease serum inflammatory factors of DKD.
