Discussion on Pathogenesis of Skeletal Muscle Cell Ferroptosis and Syndrome Differentiation and Treatment of Type 2 Diabetes Mellitus Sarcopenia Based on"Spleen Governing Transportation and Transportation and Governing Muscle"
10.11842/wst.20230718004
- VernacularTitle:基于"脾主运化,在体合肌"理论探析T2DM肌少症骨骼肌细胞铁死亡发病机制及辨证论治
- Author:
Pin LI
1
;
Ningzi ZANG
;
Chengjun GONG
;
Weiying DUAN
;
Shuang ZHANG
;
Libin ZHAN
;
Tianshu GAO
;
Jing LYU
Author Information
1. 辽宁中医药大学附属医院 沈阳 110032
- Keywords:
Spleen governing transportation;
Transportation and governing muscle;
Type 2 diabetes mellitus;
Sarcopenia;
Ferroptosis;
Pathogenesis;
Syndrome differentiation and treatment
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2024;26(7):1668-1674
- CountryChina
- Language:Chinese
-
Abstract:
The aging disease associated with type 2 diabetes mellitus(T2DM)is a hot research topic in the field of diabetes at present.Sarcopenia has become the third major complication of T2DM after microvascular and macrovascular diseases,which could lead to the occurrence and development of various adverse events such as fracture,disability,and dysfunction.The spleen belongs to the earth,is in the middle jiao,governs transportation and transformation,and governs muscle.The functional activities of the spleen manifesting in normal transformation and transportation,the distribution of cereal essence,and the nourishment of muscles are necessary for normal physiological functions to be exerted.Recent studies have shown that skeletal muscle cell ferroptosis plays an important role in the pathogenesis of T2DM sarcopenia.Based on the theory of"spleen governing transportation and transportation and governing muscle",this study explores the pathogenesis of T2DM sarcopenia from the perspectives of the pathogenesis of"dysfunction of spleen in transportation,deficiency of cereal essence,obstruction of dampness and turbidity,and muscle dystrophy"in traditional Chinese medicine and the pathological mechanism of"skeletal muscle cell ferroptosis"in modern medicine.It summarizes the principles of traditional Chinese medicine prevention and treatment for T2DM sarcopenia based on the spleen,to provide theoretical support for enriching the theoretical connotation of spleen visceral state,as well as basic research and clinical trials on the prevention and treatment of T2DM sarcopenia with traditional Chinese medicine.
