Research Progress of Traditional Chinese Medicine Compound in Prevention and Treatment of Type 2 Diabetes Based on Cell Signaling Pathway
- VernacularTitle:中药复方基于细胞信号通路防治2型糖尿病的研究进展
- Author:
Chuan PENG
1
;
Siyan RAN
;
Miao HE
;
Zhengtao CHEN
;
Yuli HU
;
Mei LI
;
Lili WU
;
Lingling QIN
;
Tonghua LIU
Author Information
- Keywords: Type 2 diabetes; Compound Chinese medicine; cell signaling pathway; research progress
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(6):1497-1504
- CountryChina
- Language:Chinese
- Abstract: As a chronic metabolic disease,type 2 diabetes poses a significant threat to human health with increasing incidence.An increasing number of studies confirm that the pathogenesis of diabetes is closely related with alterations in multiple cellular signaling pathways.Although numerous studies have reported that traditional Chinese medicine compounds prevent diabetes by modulating cell signaling pathways,asystematic review of the mechanism of action of traditional Chinese medicine compounds in modulating cell signaling pathways is still lacking.Therefore,this paper summarizes the research of type 2 diabetes prevention and treatment,which was found mainly related to the signaling pathways such as PI3K/AKT,AMPK,MAPK,NF-κB,PPAR,TGF-β.This family of signaling pathways can treat type 2 diabetes by inhibiting pancreatic islet cell apoptosis,protecting pancreatic β-cell function,ameliorating insulin resistance,inhibiting hepatic gluconeogenesis,promoting glycogen synthesis,attenuating inflammation,and resisting oxidative stress.At the same time,we analyze the problems in current research and the future development trend,in order to provide a scientific theoretical basis for the drug development and clinical application of traditional Chinese medicine compound in the prevention and treatment of diabetes.
