Clinical characteristics and therapeutic effect of drug-resistant tuberculosis in children
- VernacularTitle:儿童耐药结核病的临床特点及二线抗结核治疗效果分析
- Author:
Qiong LIAO
1
;
Shan TAN
;
Yu ZHU
;
Chaomin WAN
;
Siyan DENG
;
Min SHU
Author Information
1. 四川大学华西第二医院儿科 出生缺陷与相关妇儿疾病教育部重点实验室
- Keywords:
Child;
Tuberculosis,multidrug-resistant
- From:
Chinese Journal of Pediatrics
2017;55(2):100-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics of drug-resistant tuberculosis ( TB) in children and to study the effectiveness of second-line anti-TB therapy for children and to examine the incidence of adverse drug reactions .Method Retrospective research was conducted .The clinical records of children in West China Second Hospital diagnosed as drug-resistant TB from January 2010 to June 2014 were investigated.The clinical characteristics and risk factors were analyzed retrospectively .Treatment effect at discharge was examined as a short-term outcome indicator to evaluate the effectiveness of second-line anti-TB therapy and the incidence of adverse drug reactions .χ2 test was used.Result Forty-six patients were diagnosed as drug-resistant TB in 443 children infected with TB, with a 10.4% resistance rate.The 46 children included 26 male and 20 female patients , aged from one month and 28 days to 17 years and 5 months,with the average age ( 8.4 ±4.5 ) years, >7 to 14 years old patients as the biggest part (25 patients, 54.3%).Among the 46 children, 20 patients(43.5%)had close contact with TB patients, of whom 12 patients (60.0%) contacted with family members (including parents, brothers and sisters and grandparents living together) and 8 patients(40.0%) contacted with patients from outside family (such as relatives or neighbors).Moreover, 11 cases (23.9%) were under initial treatment and 35 cases (76.1%) were retreated.From 2010 to 2014, the number of cases of initial and retreated patients had no significant difference(0 and 1, 1 and 13, 4 and 7, 4 and 11, 2 and 3 cases,χ2 =3.255,P=0.196).Among retreated patients, 31.4% (11/35) had irregular treatment before.Until discharge, the effective rate was 87.0%(40/46), while the incidence rate of adverse drug reaction was 10.9%(5/46).Conclusion The therapy for drug-resistant TB is effective and the incidence of adverse drug reaction is relatively low .
