Evaluation of the level of urinary cysteinyl leukotriene E4 in diagnosis of bronchopulmonary dysplasia in premature infants
10.3760/cma.j.issn.0578-1310.2016.09.014
- VernacularTitle:尿半胱氨酸白三烯E4诊断支气管肺发育不良的临床评价
- Author:
Rui JIN
1
;
Hongyan LU
;
Yanyan LUO
;
Yunxian XU
;
Yuhua HU
;
Xiaoqing CHEN
Author Information
1. 210029,南京医科大学第一附属医院儿科
- Keywords:
Leukotriene E4;
Bronchopulmonary dysplasia;
Infant,newborn
- From:
Chinese Journal of Pediatrics
2016;54(9):703-707
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of urinary cysteinyl leukotriene F4 (CysLTE4) and diagnosis of bronchopulmonary dysplasia (BPD) in premature infants.Method One hundred and fifty-eight newborn infants were consecutively admitted to the neonatal intensive care units of First Affiliated Hospital of Nanjing Medical University from November 2014 to October 2015.The infants were divided into 3 groups according to the diagnosis on discharge.Sixty-one term infants were classified as having no pulmonary diseases,52 premature infants were classified as without BPD,and 45 premature infants with BPD were diagnosed at 28 d after birth.Urinary CysLTE4 levels of newborns within 3 days after birth were measured in a blinded way by enzyme-linked immunosorbent assay and were compared among 3 groups,and were evaluated for the diagnostic value and the correlation of gestational age and birth weight.Statistical analysis was performed using correlation analysis,one-way analysis of variance and x2 test etc.Result In infants with BPD,the mean urinary CysLTE4 level was (191.0 ± 29.3) ng/L which significantly higher than the premature group without BPD ((164.1 ±22.7) ng/L) and term infant group ((151.6 ±41.9) ng/L,F =18.70,P ＜ 0.05).Urinary CysLTE4 level within 3 days of life in newborn inversely correlated with gestational age and birth weight (Pearson =-0.33,-0.38,P ＜ 0.01).The area under the curve was 0.78,95％ CI:0.70-0.86,P ＜0.01,when cutoff was 187.7 ng/L,with Youden index 0.59,sensitivity 77.8％ and specificity 81.4％,respectively.Conclusion Urinary CysLTE4 level is up-regulated in BPD infants within early days of life which may be a useful biomarker of early diagnoses of BPD.
