Research Progress of Breast Cancer Organoids and Application Prospect of Traditional Chinese Medicine
- VernacularTitle:乳腺癌类器官研究进展及中医药应用展望
- Author:
Yang GAO
1
;
Sheng LIU
;
Xiqiu ZHOU
;
Youyang SHI
Author Information
- Keywords: Breast cancer; Organoids; Research progress; Traditional Chinese medicine; Outlook
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(5):1118-1124
- CountryChina
- Language:Chinese
- Abstract: Breast cancer is a highly heterogeneous malignancy,including a variety of different subtypes,which differ in genetics,pathology,clinical treatment and prognosis.The traditional research model of breast cancer cell lines cannot fully conform to the actual pathological process of clinical tumor pathogenesis and the characteristics of tumor heterogeneity.Breast cancer organoid is a model based on 3D cell culture system,which can reproduce the heterogeneity of the primary tumor while retaining the molecular phenotype and genotype changes of the patient's tumor.Therefore,it has been applied in the study of tumor pathogenesis and anti-tumor drug screening.At present,the traditional Chinese medicine research on breast cancer is mainly focused on cell lines and patient-derived tumor xenografts,while the related research on organoids is relatively lacking.This review briefly introduces the development of breast cancer organoid culture system and its application in life science research,in order to provide ideas for breast cancer related research with traditional Chinese medicine.
