Analysis of Thyroid Carcinoma Animal Model Based on Clinical Characteristics of Chinese and Western Medicine
10.11842/wst.20230314007
- VernacularTitle:基于中西医临床病症特点的甲状腺癌动物模型分析
- Author:
Yike AN
1
;
Mengfan PENG
;
Huiyan YANG
;
Hongyang DONG
;
Mingsan MIAO
Author Information
1. 河南中医药大学 郑州 450046
- Keywords:
Thyroid cancer;
Gall tumor;
Animal model;
Chinese and western medicine
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2024;26(4):951-956
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the modeling methods and standards of thyroid cancer,to provide reference for the establishment of thyroid cancer animal model close to the clinical syndrome of Chinese and Western medicine,and to promote the progress of clinical diagnosis and treatment.Methods The modeling methods and characteristics of animal models of thyroid cancer in CNKI,Wanfang,Web of Science and PubMed databases were analyzed and summarized.The advantages and disadvantages were evaluated,and the coincidence degree with the clinical characteristics of traditional Chinese and Western medicine was analyzed.Results There are many modeling methods for thyroid cancer animal models,which are mainly divided into four types:spontaneous,induced,genetic engineering and transplantation models.Genetic engineering mouse models include transgenic models,gene knockout models,gene replacement models and the latest reported restricted mouse models.Among them,the genetic engineering mouse model and the transplanted mouse model have a high clinical coincidence,and the spontaneous and induced tumor model have a low clinical coincidence.Conclusion It is one of the important directions for future research on thyroid cancer to establish an animal model consistent with"TCM syndrome"and"Western medicine diagnostic criteria".
