Animal Model of Ankylosing Spondylitis Based on Its Clinical Symptoms of Traditional Chinese and Western Medicine
- VernacularTitle:基于中西医临床病证特点的强直性脊柱炎动物模型分析
- Author:
Juanjuan YANG
1
;
Haidong WANG
;
Jinhai WANG
;
Haolin LI
;
Zhendong WANG
;
Fangmei JIN
;
Weiqing LI
;
Aihua WANG
;
Ping CHEN
Author Information
- Keywords: Ankylosing spondylitis; Animal models; Diagnostic criteria; Combination of symptoms; Anastomosis analysis
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(4):944-950
- CountryChina
- Language:Chinese
- Abstract: Ankylosing spondylitis(AS)is a typical spinal arthritis characterised by inflammatory back pain,which seriously affects the health and quality of life of patients.The clinical efficacy of Chinese medicine in the treatment of ankylosing spondylitis is clear,but the mechanism is not clear,and the existing animal models cannot be well applied to the evaluation of Chinese medicine in the treatment of ankylosing spondylitis.Therefore,this paper summarizes the existing animal models based on Chinese and Western medicine clinical diagnosis,disease characteristics,etiology and Chinese medicine evidence,and finds that among the existing animal models,the proteoglycan-induced arthritis mouse model has a higher Chinese and Western medicine clinical fit than the other models,but lacks the corresponding Chinese medicine evidence model evaluation.The other animal models had a higher Western clinical match,but lacked the characteristics of the Traditional Chinee Medicine(TCM)syndrome.As ankylosing spondylitis is a chronic inflammatory autoimmune disease with complex pathogenic factors,the existing animal models cannot better simulate the clinical symptoms.Therefore,the establishment of animal models of ankylosing spondylitis with the characteristics of Chinese and Western clinical evidence is a future research priority for AS TCM.
