Research Progress in the Treatment of Type 2 Diabetes by TCM Regulating Mitochondria-Mediated Inflammation Control
- VernacularTitle:中医药调控线粒体介导的炎症防治2型糖尿病研究进展
- Author:
Quanxing CHEN
1
;
Manxue MEI
;
Haoxiang SUN
;
Wei ZHU
;
Jianping SONG
Author Information
- Keywords: Traditional Chinese medicine; Mitochondrial inflammation; Type 2 diabetes mellitus; Mitochondrial autophagy; Mitochontrial dynamics
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(4):919-926
- CountryChina
- Language:Chinese
- Abstract: Type 2 diabetes mellitus(T2DM)is a metabolic disorder caused by excessive energy intake and insufficient consumption,which is mainly characterized by the dysfunction of islet β-cell dysfunction and insulin resistance(insulin resistance,IR).In modern medicine,oral administration of T2DM may be accompanied by adverse reactions such as liver and kidney function injury.Studies have proved that traditional Chinese medicine has the significant superiority of multi-target,multi-component and multi-pathway.Mitochondria are the main organelles for cells to provide energy.They supply energy to ATP through oxidative phosphorylation(OXPHOS)reaction to maintain the functional balance of cells.There are closely related to the occurrence of T2DM between mitochondrial dysfunction,abnormal mitochondrial dynamics and impaired mitochondrial autophagy.Mitochondria has been gradually confirmed as the target of traditional Chinese medicine in the treatment of diabetes,but there is a lack of an overview of the effects of traditional Chinese medicine on T2DM by regulating mitochondrial-mediated inflammation.Therefore,this paper reviews the relationship between mitochondrial-mediated inflammation and T2DM,and the mechanism of traditional Chinese medicine to interfere with T2DM by regulating mitochondrial-mediated inflammation.
